Aquaporins in the Kidney: From Molecules to Medicine

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 • 1,979 citations

Structural determinants of water permeation through aquaporin-1

2000 • 1,710 citations

Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

1997 • 1,396 citations

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

1995 • 1,017 citations

Cloning and expression of apical membrane water channel of rat kidney collecting tubule

1993 • 1,002 citations

Structure of a Glycerol-Conducting Channel and the Basis for Its Selectivity

2000 • 980 citations

Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine

1994 • 870 citations

Cellular and Molecular Biology of the Aquaporin Water Channels

1999 • 823 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

1993 • 761 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

1993 • 709 citations

Aquaporin CHIP: the archetypal molecular water channel

1993 • 670 citations

Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.

1988 • 669 citations

Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

1994 • 632 citations

Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord

1998 • 593 citations

Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

1992 • 588 citations

The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

1993 • 580 citations

Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells.

1994 • 575 citations

Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels

1998 • 553 citations

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.

1993 • 543 citations

Rapid gating and anion permeability of an intracellular aquaporin

1999 • 492 citations

Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2, and S3 segments

1978 • 490 citations

Molecular Characterization of a Broad Selectivity Neutral Solute Channel

1998 • 465 citations

Phosphorylation of Serine 256 Is Required for cAMP-dependent Regulatory Exocytosis of the Aquaporin-2 Water Channel

1997 • 465 citations

The Aquaporins, Blueprints for Cellular Plumbing Systems

1998 • 457 citations

The three-dimensional structure of aquaporin-1

1997 • 451 citations

Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.

1997 • 447 citations

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

1995 • 437 citations

Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice

1998 • 437 citations

Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Müller Cells and Fibrous Astrocytes

1998 • 423 citations

Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat

1997 • 409 citations

Aquaporin-3 water channel localization and regulation in rat kidney

1995 • 400 citations

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.

1994 • 395 citations

Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues

1995 • 392 citations

Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels

2000 • 386 citations

Cloning and Functional Expression of a New Water Channel Abundantly Expressed in the Testis Permeable to Water, Glycerol, and Urea

1997 • 379 citations

Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

1991 • 378 citations

Effect of expressing the water channel aquaporin-1 on the CO₂ permeability ofXenopus oocytes

1998 • 375 citations

Long-term regulation of four renal aquaporins in rats

1996 • 366 citations

Prevalence, Pathogenesis, and Treatment of Renal Dysfunction Associated With Chronic Lithium Therapy

1987 • 348 citations

Phylogenetic Characterization of the MIP Family of Transmembrane Channel Proteins

1996 • 314 citations

Mutations in aquaporin-1 in Phenotypically Normal Humans Without Functional CHIP Water Channels

1994 • 312 citations

Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells

1997 • 306 citations

Physiology and Pathophysiology of Renal Aquaporinsa

1999 • 305 citations

Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct

1995 • 303 citations

Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye

1998 • 300 citations

An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis

1975 • 296 citations

Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex.

1996 • 295 citations

Hyponatremia in cirrhosis: From pathogenesis to treatment

1998 • 294 citations

ADH ACTION: EVIDENCE FOR A MEMBRANE SHUTTLE MECHANISM*

1981 • 291 citations

Upregulation of aquaporin-2 water channel expression in chronic heart failure rat.

1997 • 289 citations

Localization of the CHIP28 water channel in rat kidney

1992 • 284 citations

Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin

1997 • 280 citations

Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats.

1997 • 280 citations

Three-dimensional organization of a human water channel

1997 • 278 citations

Cloning and Functional Expression of a New Aquaporin (AQP9) Abundantly Expressed in the Peripheral Leukocytes Permeable to Water and Urea, but Not to Glycerol

1998 • 277 citations

Distribution of aquaporin-4 water channel expression within rat kidney

1995 • 270 citations

Urinary Excretion of Aquaporin-2 in Patients with Diabetes Insipidus

1995 • 266 citations

Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney.

1994 • 264 citations

An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex.

1998 • 257 citations

The Mercurial Insensitive Water Channel (AQP-4) Forms Orthogonal Arrays in Stably Transfected Chinese Hamster Ovary Cells

1996 • 254 citations

Membrane associated particles: Distribution in frog urinary bladder epithelium at rest and after oxytocin treatment

1974 • 249 citations

Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia

1999 • 249 citations

Role of microtubules in polarized delivery of apical membrane proteins to the brush border of the intestinal epithelium.

1989 • 240 citations

Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study.

1993 • 238 citations

Functional and molecular characterization of the human neutral solute channel aquaporin-9

1999 • 235 citations

The AQP2 water channel: Effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats

1995 • 231 citations

Selective vulnerability of the medullary thick ascending limb to anoxia in the isolated perfused rat kidney.

1984 • 229 citations

Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat.

1997 • 228 citations

Transcriptional regulation of aquaporin-2 water channel gene by cAMP.

1997 • 228 citations

Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney

1995 • 223 citations

Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4

1997 • 222 citations

Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways

2001 • 222 citations

Urinary tract obstruction

2001 • 220 citations

Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct.

1988 • 220 citations

Defective Urinary Concentrating Ability Due to a Complete Deficiency of Aquaporin-1

2001 • 219 citations

cAMP-dependent Phosphorylation Stimulates Water Permeability of Aquaporin-collecting Duct Water Channel Protein Expressed in Xenopus Oocytes

1995 • 217 citations

Biologically active two-dimensional crystals of aquaporin CHIP.

1994 • 211 citations

Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice

1999 • 210 citations

Vasopressin: Induced Structural Change in Toad Bladder Luminal Membrane

1975 • 209 citations

An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus

1999 • 206 citations

Ultrastructure, Pharmacologic Inhibition, and Transport Selectivity of Aquaporin CHIP in Proteoliposomes

1994 • 206 citations

Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats

1995 • 204 citations

Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.

1994 • 204 citations

Transport of Water and Glycerol in Aquaporin 3 Is Gated by H+

1999 • 203 citations

Functional reconstitution of the isolated erythrocyte water channel CHIP28.

1992 • 202 citations

Cloning of a Novel Water and Urea-Permeable Aquaporin from Mouse Expressed Strongly in Colon, Placenta, Liver, and Heart

1997 • 199 citations

Localization and regulation of PKA-phosphorylated AQP2 in response to V₂-receptor agonist/antagonist treatment

2000 • 197 citations

The Water Channel Aquaporin-8 Is Mainly Intracellular in Rat Hepatocytes, and Its Plasma Membrane Insertion Is Stimulated by Cyclic AMP

2001 • 195 citations

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct

1997 • 193 citations

Evolution of the MIP family of integral membrane transport proteins

1991 • 192 citations

Cloning and Functional Expression of a Second New Aquaporin Abundantly Expressed in Testis

1997 • 191 citations

Carbon Dioxide Permeability of Aquaporin-1 Measured in Erythrocytes and Lung of Aquaporin-1 Null Mice and in Reconstituted Proteoliposomes

2000 • 186 citations

Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney

1996 • 183 citations

Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle.

1998 • 183 citations

Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements

1997 • 181 citations

Cloned Human Aquaporin-1 Is a Cyclic GMP-Gated Ion Channel

2000 • 176 citations

Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney.

1994 • 176 citations

Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells.

1995 • 173 citations

Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels

1996 • 169 citations

Effect of PCMBS on CO₂permeability of Xenopus oocytes expressing aquaporin 1 or its C189S mutant

1998 • 168 citations

Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice

1998 • 168 citations

Bidirectional Water Fluxes and Specificity for Small Hydrophilic Molecules in Aquaporins 0–5

1998 • 167 citations

Water Channel Protein AQP3 Is Present in Epithelia Exposed to the Environment of Possible Water Loss

1999 • 165 citations

Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

1994 • 163 citations

Altered expression of renal AQPs and Na⁺transporters in rats with Lithium-induced NDI

2000 • 161 citations

Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen.

1987 • 160 citations

cAMP motifs regulating transcription in the aquaporin 2 gene

1996 • 160 citations

Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles. Colocalization with Aquaporin-2 water channels.

1995 • 158 citations

Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats

1998 • 155 citations

Isolation of Human Aquaporin 3 Gene

1995 • 152 citations

UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin

2000 • 147 citations

Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice

1999 • 146 citations

THE INFLUENCE OF BODILY HYDRATION ON THE RENAL CONCENTRATING PROCESS 1

1957 • 144 citations

Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats.

1998 • 144 citations

Osmoregulation during Pregnancy in the Rat

1981 • 143 citations

Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats

1995 • 143 citations

Aquaporin-1 water channel expression in human kidney.

1997 • 142 citations

Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats.

1985 • 142 citations

Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.

1996 • 137 citations

Prostaglandin E₂interaction with AVP: effects on AQP2 phosphorylation and distribution

2000 • 137 citations

Peripheral arterial vasodilation hypothesis of sodium and water retention in pregnancy: implications for pathogenesis of preeclampsia-eclampsia.

1991 • 137 citations

Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue

1999 • 134 citations

The effect of a high water intake on the kidney's ability to concentrate the urine in man

1957 • 133 citations

cDNA Cloning, Gene Organization, and Chromosomal Localization of a Human Mercurial Insensitive Water Channel

1995 • 133 citations

Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect

2001 • 132 citations

Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.

1994 • 131 citations

Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus

1999 • 128 citations

Effects of renal artery occlusion on kidney function in the rat

1973 • 128 citations

A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k

1993 • 127 citations

In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats

1996 • 124 citations

Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta

2000 • 123 citations

Selective V2-Receptor Vasopressin Antagonism Decreases Urinary Aquaporin-2 Excretion in Patients with Chronic Heart Failure

1999 • 122 citations

Urinary Excretion of Aquaporin-2 in Rat Is Mediated by a Vasopressin-Dependent Apical Pathway

1999 • 121 citations

Effects of Ca++ and Prostaglandin E1 on Vasopressin Activation of Renal Adenyl Cyclase

1971 • 121 citations

The three-dimensional structure of human erythrocyte aquaporin CHIP.

1994 • 120 citations

Water and Ion Permeation of Aquaporin-1 in Planar Lipid Bilayers

2001 • 119 citations

Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass

1998 • 116 citations

Concentrating defect in experimental nephrotic syndrome: Altered expression of aquaporins and thick ascending limb Na+ transporters

1998 • 115 citations

Urinary excretion of aquaporin-2 water channel protein in human and rat.

1997 • 113 citations

Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.

1997 • 112 citations

Vasopressin-Resistant Hyposthenuria in Advanced Chronic Renal Disease

1969 • 110 citations

Upregulation of aquaporin 2 water channel expression in pregnant rats.

1998 • 109 citations

Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction

1997 • 107 citations

Reduced renal medullary water channel expression in puromycin aminonucleoside--induced nephrotic syndrome.

1997 • 107 citations

Tandem sequence repeats in transmembrane channel proteins

1991 • 106 citations

Increased gene expression of water channel in cirrhotic rat kidneys

1995 • 104 citations

Mechanism of vasopressin action in the renal collecting duct.

1994 • 103 citations

Relationship of aggregated intramembranous particles to water permeability in vasopressin-treated toad urinary bladder.

1977 • 103 citations

Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice

2000 • 103 citations

Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by α-MSH

1999 • 101 citations

cDNA Cloning and Gene Structure of a Novel Water Channel Expressed Exclusively in Human Kidney: Evidence for a Gene Cluster of Aquaporins at Chromosome Locus 12q13

1996 • 101 citations

Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD

1992 • 97 citations

Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro.

1995 • 95 citations

Oxytocin as an antidiuretic hormone. II. Role of V2 vasopressin receptor

1995 • 95 citations

Structure of Aquaporin-2 Vasopressin Water Channel

1996 • 91 citations

Surface Topographies at Subnanometer-resolution Reveal Asymmetry and Sidedness of Aquaporin-1

1996 • 91 citations

Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA.

1995 • 91 citations

Evidence for dual signaling pathways for V2 vasopressin receptor in rat inner medullary collecting duct

1996 • 90 citations

Phosphorylation of Aquaporin-2 Does Not Alter the Membrane Water Permeability of Rat Papillary Water Channel-containing Vesicles

1996 • 89 citations

Isolation of human aquaporin-CD gene.

1994 • 89 citations

Regulation of collecting duct water permeability independent of cAMP-mediated AVP response

1991 • 87 citations

Functional Profile of the Isolated Uremic Nephron

1978 • 86 citations

Expression and Functional Analysis of Water Channels in a Stably AQP2-transfected Human Collecting Duct Cell Line

1996 • 86 citations

Vasopressin depolymerizes F-actin in toad bladder epithelial cells

1991 • 86 citations

Direct demonstration of aquaporin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells

1996 • 85 citations

SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles

1998 • 84 citations

Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis

1999 • 84 citations

Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus.

1996 • 83 citations

Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis

2000 • 81 citations

Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct

1998 • 81 citations

Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct

1998 • 79 citations

Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes.

1988 • 79 citations

Particle aggregates in plasma and intracellular membranes of toad bladder (granular cell)

1977 • 79 citations

Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.

1995 • 78 citations

Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus

2001 • 78 citations

Cyclic AMP—Dependent Reversible Phosphorylation of Renal Medullary Plasma Membrane Protein

1972 • 77 citations

PGE2 inhibits water permeability at a post-cAMP site in rat terminal inner medullary collecting duct

1992 • 76 citations

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

2000 • 76 citations

Decreased Abundance of Collecting Duct Aquaporins in Post-Ischemic Renal Failure in Rats

1999 • 74 citations

Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome

1998 • 72 citations

Functional heterogeneity of the descending limbs of Henle's loop

1984 • 72 citations

Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct

1995 • 71 citations

Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography

1999 • 71 citations

ADH-sensitive cAMP system in papillary collecting duct: effect of osmolality and PGE2

1981 • 71 citations

Extracellular ATP increases intracellular calcium in rat terminal collecting duct via a nucleotide receptor

1994 • 70 citations

Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor.

1996 • 69 citations

Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex

2000 • 69 citations

Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP

1996 • 68 citations

Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis

1998 • 68 citations

Functional Profile of the Isolated Uremic Nephron

1978 • 67 citations

In vitro perfusion of chinchilla thin limb segments: segmentation and osmotic water permeability

1992 • 67 citations

Renal sodium retention in cirrhosis: Tubular site and relation to hepatic dysfunction

1988 • 67 citations

Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats

1998 • 66 citations

Expression of syntaxins in rat kidney

1997 • 65 citations

Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel

1994 • 65 citations

cAMP Regulated Membrane Diffusion of a Green Fluorescent Protein-Aquaporin 2 Chimera

2000 • 65 citations

V2-like vasopressin receptor mobilizes intracellular Ca2+ in rat medullary collecting tubules

1993 • 65 citations

Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping

1998 • 65 citations

Alteration in water channel AQP-2 by removal of AVP stimulation in collecting duct cells of dehydrated rats

1997 • 65 citations

Oxytocin as an antidiuretic hormone. I. Concentration dependence of action

1995 • 62 citations

Vasopressin V₂-receptor-dependent regulation of AQP2 expression in Brattleboro rats

2000 • 61 citations

Urine Concentration after Fluid Deprivation or Pitressin Tannate in Oil

1956 • 59 citations

Cloning and functional expression of rAQP9L a new member of aquaporin family from rat liver

1999 • 59 citations

Possible roles for microtubules and microfilaments in ADH action on toad urinary bladder

1979 • 59 citations

Regulation of Aquaporin mRNA Expression in Rat Kidney by Water Intake

1999 • 59 citations

Urinary concentrating ability during dehydration in the absence of vasopressin

1979 • 59 citations

Isolated nephron segments in a rabbit model of ischemic acute renal failure

1980 • 58 citations

Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats

2002 • 58 citations

Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells

2000 • 58 citations

Cloning of a Novel Rat Kidney cDNA Homologous to CHIP28 and WCH-CD Water Channels

1993 • 57 citations

In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities

1993 • 57 citations

Renal Expression of Aquaporins in Liver Cirrhosis Induced by Chronic Common Bile Duct Ligation in Rats

1999 • 57 citations

Acute effects of vasopressin V₂-receptor antagonist on kidney AQP2 expression and subcellular distribution

1998 • 56 citations

Localization and expression of a collecting duct water channel, aquaporin, in hydrated and dehydrated rats.

1995 • 55 citations

Phosphoinositide signaling in rat inner medullary collecting duct

1998 • 52 citations

Vasopressin increases water permeability by inducing pores

1980 • 52 citations

Water permeability of apical and basolateral cell membranes of rat inner medullary collecting duct

1990 • 50 citations

Molecular physiology of water transport: Aquaporin nomenclature workshop. Mammalian aquaporins

1997 • 49 citations

Vanadate blocks cyclic AMP-induced Stimulation of sodium and water transport in amphibian epithelia

1979 • 48 citations

Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels

1995 • 47 citations

Cytoplasmic involvement in ADH-mediated osmosis across toad urinary bladder

1983 • 46 citations

Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct

1993 • 46 citations

Actin filaments and vasopressin-stimulated water flow in toad urinary bladder

1983 • 46 citations

Response of deep nephrons and the terminal collecting duct to a reduction in renal mass

1979 • 45 citations

Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity

1999 • 44 citations

Functional and structural changes in the thick ascending limb of Henle's loop in rats with liver cirrhosis

1997 • 44 citations

Role of the cytoskeleton in the control of transcellular water flow by vasopressin in amphibian urinary bladder

1985 • 43 citations

Hepatic denervation alters first-phase urinary sodium excretion in dogs with cirrhosis

1987 • 43 citations

Interaction between catecholamines and vasopressin on renal medullary cyclic AMP of rat

1973 • 41 citations

Aggregate-carrying membranes during ADH stimulation and washout in toad bladder

1984 • 41 citations

Recovery of proximal tubular function from ischemic injury

1984 • 41 citations

Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus

1998 • 39 citations

Renal concentration defect following nonoliguric acute renal failure in the rat

1982 • 39 citations

Structural-functional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment

1993 • 39 citations

cAMP-dependent protein kinase mediates hydrosmotic effect of vasopressin in collecting duct

1992 • 37 citations

Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules perfused in vitro.

1989 • 37 citations

Repressive regulation of the aquaporin-2 gene

1996 • 36 citations

Effect of ovariectomy and treatment with ovarian steroids on vasopressin release and fluid balance in the rat

1990 • 35 citations

Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade

2000 • 34 citations

Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis

1990 • 34 citations

Cytochalasin B inhibition of toad bladder apical membrane responses to ADH

1988 • 32 citations

Vasopressin-independent regulation of collecting duct water permeability

1994 • 31 citations

Ochratoxin A Secretion in Primary Cultures of Rabbit Renal Proximal Tubule Cells

1999 • 30 citations

Freeze-Fracture Analysis of Plasma Membranes of CHO Cells Stably Expressing Aquaporins 1-5

1998 • 30 citations

Ischemia-induced changes in cell element composition and osmolyte contents of outer medulla

1995 • 29 citations

Interstitial water and solute recovery by inner medullary vasa recta

2000 • 28 citations

Vesicle fusion proteins in rat inner medullary collecting duct and amphibian bladder

1995 • 27 citations

Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules.

1992 • 26 citations

Effect of a dynein inhibitor on vasopressin action in toad urinary bladder.

1996 • 25 citations

Effects of cellular acidification on ADH-induced intramembrane particle aggregates

1984 • 25 citations

GFR and the concentration of urine in the absence of vasopressin. Berliner-Davidson re-explored

1987 • 24 citations

Aquaporin-2 Water Channels and Vasopressin Antagonists in Edematous Disorders

1998 • 23 citations

Studies of Renal Aquaporin-2 Expression during Renal Escape from Vasopressin-Induced Antidiuresis

1998 • 23 citations

To what extent is microtubular network involved in antidiuretic response?

1988 • 22 citations

Medullary collecting duct function in the remnant kidney before and after volume expansion

1979 • 22 citations

Effect of glutaraldehyde on renal tubular function

1987 • 20 citations

Cellular pH and water permeability control in frog urinary bladder a possible action on the water pathway

1981 • 20 citations

Intracellular pH, transepithelial pH gradients, and ADH-induced water channels

1983 • 19 citations

Induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus

1991 • 19 citations

Effect of hypotonicity on cyclic adenosine monophosphate formation and action in vasopressin target cells

1975 • 18 citations

Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus

1998 • 17 citations

The rate-limiting step in hydrosmotic response of frog urinary bladder

1983 • 17 citations

Focus on “Effect of expressing the water channel aquaporin-1 on the CO₂ permeability ofXenopus oocytes”

1998 • 16 citations

cAMP-binding proteins in medullary tubules from rat kidney: effect of ADH

1988 • 13 citations

Long-term regulation of collecting duct water permeability: freeze-fracture analysis of isolated perfused tubules

1994 • 12 citations

Prolonged Disappearance Rate of a Structurally Abnormal Mutant Insulin from the Circulation in Humans*

1985 • 9 citations

Molecular biology of Na+/glucose cotransport

1989 • 7 citations

Electrogenic Cotransport of Na+, Sulfate (s-I) and Phosphate (p-I) in Xenopus Oocytes Expressing the Cloned Transport Proteins Nasi-1 and Napi-2

1995 • 2 citations