The Aquaporins, Blueprints for Cellular Plumbing Systems

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Life with 6000 Genes

1996 • 4,125 citations

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 • 1,979 citations

Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

1997 • 1,396 citations

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

1995 • 1,017 citations

Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine

1994 • 870 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

1993 • 761 citations

Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.

1988 • 669 citations

Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

1994 • 632 citations

AQUAPORINS AND WATER PERMEABILITY OF PLANT MEMBRANES

1997 • 563 citations

Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels

1998 • 553 citations

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.

1993 • 543 citations

The three-dimensional structure of aquaporin-1

1997 • 451 citations

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

1995 • 437 citations

Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Müller Cells and Fibrous Astrocytes

1998 • 423 citations

Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat

1997 • 409 citations

Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues

1995 • 392 citations

Cloning and Functional Expression of a New Water Channel Abundantly Expressed in the Testis Permeable to Water, Glycerol, and Urea

1997 • 379 citations

Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

1991 • 378 citations

Effect of expressing the water channel aquaporin-1 on the CO₂ permeability ofXenopus oocytes

1998 • 375 citations

Cotransport of water by the Na ⁺ /glucose cotransporter

1996 • 345 citations

Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts

1995 • 341 citations

Phylogenetic Characterization of the MIP Family of Transmembrane Channel Proteins

1996 • 314 citations

Mutations in aquaporin-1 in Phenotypically Normal Humans Without Functional CHIP Water Channels

1994 • 312 citations

Mutations in the founder of the MIP gene family underlie cataract development in the mouse

1996 • 266 citations

The Major Intrinsic Protein Family of Arabidopsis Has 23 Members That Form Three Distinct Groups with Functional Aquaporins in Each Group

1997 • 249 citations

Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4

1997 • 222 citations

Ultrastructure, Pharmacologic Inhibition, and Transport Selectivity of Aquaporin CHIP in Proteoliposomes

1994 • 206 citations

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct

1997 • 193 citations

Molecular Cloning and Expression of a Novel Human Aquaporin from Adipose Tissue with Glycerol Permeability

1997 • 178 citations

Molecular Cloning of a New Aquaporin from Rat Pancreas and Liver

1997 • 178 citations

Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels

1996 • 169 citations

Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice

1998 • 168 citations

Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

1994 • 163 citations

Regulation of aquaporin-2 water channel trafficking by vasopressin

1997 • 160 citations

Regulation of Aquaporin-4 Water Channels by Phorbol Ester-dependent Protein Phosphorylation

1998 • 147 citations

Renal aquaporins

1996 • 142 citations

Aquaporin-1 water channel expression in human kidney.

1997 • 142 citations

The Aquaporin Family of Water Channel Proteins in Clinical Medicine

1997 • 113 citations

Upregulation of aquaporin 2 water channel expression in pregnant rats.

1998 • 109 citations

cDNA Cloning and Gene Structure of a Novel Water Channel Expressed Exclusively in Human Kidney: Evidence for a Gene Cluster of Aquaporins at Chromosome Locus 12q13

1996 • 101 citations

Perinatal changes in expression of aquaporin‐4 and other water and ion transporters in rat lung

1997 • 88 citations

Regulation of the Escherichia coli water channel gene aqpZ

1998 • 88 citations

AQUAPORIN-2 AND -3: Representatives of Two Subgroups of the Aquaporin Family Colocalized in the Kidney Collecting Duct

1998 • 80 citations

Structural Analysis of a MIP Family Protein from the Digestive Tract of Cicadella viridis

1995 • 72 citations

Adenovirus-mediated Expression of Aquaporin-5 in Epithelial Cells

1996 • 67 citations

The wacA gene of Dictyostelium discoideum is a developmentally regulated member of the MIP family

1997 • 27 citations

Distribution of mRNA encoding the FA-CHIP water channel in amphibian tissues: Effects of salt adaptation

1995 • 20 citations