The Set2 Histone Methyltransferase Functions through the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

A generic protein purification method for protein complex characterization and proteome exploration

1999 • 2,699 citations

Active genes are tri-methylated at K4 of histone H3

2002 • 2,064 citations

The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification

2001 • 1,792 citations

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

2001 • 1,480 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

2002 • 1,050 citations

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

2000 • 1,049 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Histone methylation in transcriptional control

2002 • 887 citations

Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core

2002 • 818 citations

Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain

2002 • 811 citations

Methylation of histone H3 Lys 4 in coding regions of active genes

2002 • 742 citations

ATP-Dependent Chromatin-Remodeling Complexes

2000 • 734 citations

COMPASS: A complex of proteins associated with a trithorax-related SET domain protein

2001 • 589 citations

The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4

2001 • 586 citations

Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

2000 • 562 citations

Set2 Is a Nucleosomal Histone H3-Selective Methyltransferase That Mediates Transcriptional Repression

2002 • 557 citations

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation

2002 • 555 citations

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

1997 • 546 citations

Function and Selectivity of Bromodomains in Anchoring Chromatin-Modifying Complexes to Promoter Nucleosomes

2002 • 526 citations

Histone Methylation

2002 • 525 citations

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

2002 • 520 citations

Trans-histone regulatory pathway in chromatin

2002 • 502 citations

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

1999 • 482 citations

mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain

1997 • 467 citations

Global histone acetylation and deacetylation in yeast

2000 • 457 citations

A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme

1999 • 453 citations

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

2001 • 441 citations

Promoter targeting and chromatin remodeling by the SWI/SNF complex

2000 • 433 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79

2002 • 424 citations

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

1998 • 421 citations

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

2001 • 421 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit

2001 • 369 citations

Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription

2001 • 364 citations

Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes

2001 • 359 citations

Distinct Roles for CTD Ser-2 and Ser-5 Phosphorylation in the Recruitment and Allosteric Activation of Mammalian mRNA Capping Enzyme

1999 • 329 citations

Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

1998 • 319 citations

The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

1991 • 319 citations

Methylation at arginine 17 of histone H3 is linked to gene activation

2002 • 319 citations

Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1

2002 • 312 citations

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

2001 • 310 citations

Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II

1987 • 306 citations

Disruptor of Telomeric Silencing-1 Is a Chromatin-specific Histone H3 Methyltransferase

2002 • 294 citations

A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure

1998 • 277 citations

Association of the Histone Methyltransferase Set2 with RNA Polymerase II Plays a Role in Transcription Elongation

2002 • 259 citations

6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae

1992 • 254 citations

Histone H3 Lysine 4 Methylation Disrupts Binding of Nucleosome Remodeling and Deacetylase (NuRD) Repressor Complex

2002 • 247 citations

Activation Domain–Mediated Targeting of the SWI/SNF Complex to Promoters Stimulates Transcription from Nucleosome Arrays

1999 • 245 citations

Ctr9, Rtf1, and Leo1 Are Components of the Paf1/RNA Polymerase II Complex

2002 • 242 citations

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

1995 • 239 citations

Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators

1999 • 234 citations

Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter

2001 • 220 citations

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1992 • 219 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

Transcription elongation factor SII

2000 • 207 citations

Control of elongation by RNA polymerase II

2000 • 206 citations

Mechanism of Transcription Through the Nucleosome by Eukaryotic RNA Polymerase

1997 • 205 citations

GENETICS OF TRANSCRIPTIONAL REGULATION IN YEAST: Connections to the RNA Polymerase II CTD

1997 • 202 citations

An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae

1999 • 198 citations

Regulation of transcription elongation by phosphorylation

2002 • 188 citations

Ssn6–Tup1 interacts with class I histone deacetylases required for repression

2000 • 172 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

Overcoming a nucleosomal barrier to transcription

1995 • 168 citations

A CTD function linking transcription to splicing

1997 • 160 citations

Transcriptional Activation by Gcn4p Involves Independent Interactions with the SWI/SNF Complex and the SRB/Mediator

1999 • 156 citations

Evidence for a mediator cycle at the initiation of transcription

1997 • 126 citations

Purification and lipid-layer crystallization of yeast RNA polymerase II.

1990 • 113 citations

Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain by the Bur1 Cyclin-Dependent Kinase

2001 • 98 citations

RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.

1991 • 85 citations

Mechanism and regulation of transcriptional elongation by RNA polymerase II

1999 • 81 citations

Genetic Interactions between TFIIS and the Swi-Snf Chromatin-Remodeling Complex

2000 • 74 citations

HDAC's at Work

2002 • 69 citations

Yeast RNA Polymerase II Transcription Reconstituted with Purified Proteins

1997 • 41 citations

Zinc Stoichiometry of Yeast RNA Polymerase II and Characterization of Mutations in the Zinc-binding Domain of the Largest Subunit

2000 • 36 citations

Transcriptional Control: An Activating Role for Arginine Methylation

2002 • 33 citations

Identification and Analysis of Native Nucleosomal Histone Acetyltransferase Complexes

2003 • 17 citations