Blocking effect of human serum but not of cerebrospinal fluid on ricin A chain immunotoxin potentiation by monensin or carrier protein-monensin conjugates.

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Mechanism of action of the toxic lectins abrin and ricin

1974 • 443 citations

Monoclonal Antibodies in Diagnosis and Therapy

1991 • 378 citations

Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody-ricin A chain immunotoxin.

1987 • 212 citations

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

1987 • 205 citations

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

1982 • 200 citations

Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.

1984 • 194 citations

Immunotoxins: Hybrid Molecules Combining High Specificity and Potent Cytotoxicity

1982 • 181 citations

Immunology of the Nervous System

1983 • 150 citations

Inhibition of Human Acute Lymphoblastic Leukemia Cells by Immunotoxins: Potentiation by Chloroquine

1984 • 124 citations

Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

1989 • 111 citations

Use of an anti-pan T-lymphocyte ricin a chain immunotoxin in steroid- resistant acute graft-versus-host disease

1990 • 105 citations

Effects of therapy with T101 ricin A-chain immunotoxin in two leukemia patients

1986 • 89 citations

Characterization of immunotoxins active against ovarian cancer cell lines.

1985 • 86 citations

Evaluation of ricin A-chain immunotoxins directed against human T cells

1986 • 85 citations

Importance of the Antigen-Binding Valency and the Nature of the Cross-Linking Bond in Ricin A-Chain Conjugates with Antibody

1982 • 84 citations

Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin

1987 • 80 citations

Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.

1984 • 79 citations

Kinetics and mechanisms of the aminolysis of N-hydroxysuccinimide esters in aqueous buffers

1988 • 77 citations

Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice.

1990 • 76 citations

Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin.

1991 • 70 citations

Selective antitumor effect on L10 hepatocarcinoma cells of a potent immunoconjugate composed of the A chain of abrin and a monoclonal antibody to a hepatoma-associated antigen.

1984 • 67 citations

Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.

1987 • 67 citations

Antibody Toxin Conjugates: A Perspective

2015 • 66 citations

Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia

1988 • 51 citations

Determination of sensitivity of fresh leukemia cells to immunotoxins.

1986 • 50 citations

Potentiation of cytotoxic activity of immunotoxins on cultured human cells.

1985 • 46 citations

Effect of linkage variation on pharmacokinetics of ricin A chain-antibody conjugates in normal rats.

1986 • 45 citations

Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide-linked pokeweed antiviral protein-antibody conjugates from blood.

1985 • 43 citations

Sensitivity of human glioma cells to cytotoxic heteroconjugates

1988 • 36 citations

Carrier protein-monensin conjugates: enhancement of immunotoxin cytotoxicity and potential in tumor treatment.

1990 • 36 citations

Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.

1987 • 34 citations

Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin.

1990 • 34 citations

Selective killing of human T-lymphotropic virus-I infected leukemic T-cells by monoclonal anti-interleukin 2 receptor antibody-ricin A chain conjugates: potentiation by ammonium chloride and monensin.

1986 • 29 citations

Mediation of reduction of spontaneous and experimental pulmonary metastases by ricin A-chain immunotoxin 45-2D9-RTA with potentiation by systemic monensin in mice.

1988 • 29 citations

T-lymphocyte killing by T101-ricin A-chain immunotoxin: pH-dependent potentiation with lysosomotropic amines

1988 • 21 citations

Intra‐thecal treatment of leptomeningeal lymphoma with immunotoxin

1991 • 19 citations

Parameters affecting tumor-specific delivery of anti-CD5 antibody-ricin A chain immunotoxins in vivo.

1990 • 8 citations

Morphological Heterogeneity and Phenotype Modifications during Long Term in Vitro Cultures of Six New Human Glioblastoma Cell Lines

1990 • 7 citations