[1] Studying ribosome structure by electron microscopy and computer-image processing

Hierarchical clustering schemes

1967 • 4,697 citations

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Iterative methods for the three-dimensional reconstruction of an object from projections

1972 • 1,311 citations

Reconstruction of Three Dimensional Structures from Electron Micrographs

1968 • 1,297 citations

Cryo-electron microscopy of viruses

1984 • 1,293 citations

Molecular structure determination by electron microscopy of unstained crystalline specimens

1975 • 1,142 citations

Image Reconstruction from Projections

2004 • 939 citations

Multivariate Descriptive Statistical Analysis.

1985 • 882 citations

The correlation averaging of a regularly arranged bacterial cell envelope protein

1982 • 861 citations

Continuous Shading of Curved Surfaces

1971 • 708 citations

A guided tour of the fast Fourier transform

1969 • 673 citations

Use of multivariate statistics in analysing the images of biological macromolecules

1981 • 579 citations

Three-dimensional structure determination by electron microscopy of two-dimensional crystals

1982 • 512 citations

Electron microscopy of an antibody-hapten complex

1967 • 505 citations

Three‐dimensional reconstruction from a single‐exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

1987 • 500 citations

Electron Diffraction of Frozen, Hydrated Protein Crystals

1974 • 423 citations

Computer Averaging of Electron Micrographs of 40 S Ribosomal Subunits

1981 • 377 citations

Digital image processing: The semper system

1979 • 355 citations

Measurement and compensation of defocusing and aberrations by Fourier processing of electron micrographs

1971 • 346 citations

Image reconstruction from projections

1981 • 325 citations

Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes

1976 • 296 citations

SPIDER—A modular software system for electron image processing

1981 • 287 citations

Advanced Techniques in Biological Electron Microscopy

1974 • 276 citations

Multivariate statistical classification of noisy images (randomly oriented biological macromolecules)

1984 • 270 citations

Notizen: Zur Defokussierungsabhängigkeit des Phasenkontrastes bei der elektronenmikroskopischen Abbildung

1966 • 258 citations

Reconstruction of glutamine synthetase using computer averaging

1978 • 255 citations

Modern methods in protein chemistry

1983 • 221 citations

Methodologies of Pattern Recognition

1969 • 218 citations

IMAGIC: A fast, flexible and friendly image analysis software system

1981 • 207 citations

Characteristic views of E. coli and B. stearothermophilus 30S ribosomal subunits in the electron microscope.

1985 • 177 citations

Correspondence analysis of aligned images of biological particles

1982 • 174 citations

Electron Microscopy in Material Science

1971 • 149 citations

Determination of the location of proteins L14, L17, L18, L19, L22 and L23 on the surface of the 50S ribosomal subunit of Escherichia coli by immune electron microscopy

1974 • 144 citations

Techniques de la Description Statistique.

1979 • 141 citations

Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein

1974 • 134 citations

A NEW 3‐D RECONSTRUCTION SCHEME APPLIED TO THE 50S RIBOSOMAL SUBUNIT OF E. COLI

1986 • 120 citations

Multivariate statistical analysis of ribosome electron micrographs

1982 • 115 citations

Determination of a common origin in the micrographs of tilt series in three-dimensional electron microscopy

1982 • 114 citations

Three-dimensional structure of the large ribosomal subunit from Escherichia coli.

1987 • 110 citations

Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli

1988 • 106 citations

The “EM” program system

1982 • 103 citations

Technique de la Description Statistique

1978 • 97 citations

Direct structural localization of two toxin-recognition sites on an ACh receptor protein

1982 • 95 citations

Three-dimensional reconstruction of the 30 S ribosomal subunit from randomly oriented particles

1984 • 84 citations

Classification of images of biomolecular assemblies: a study of ribosomes and ribosomal subunits of Escherichia coli

1988 • 82 citations

Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein

1974 • 80 citations

Principles of electron structure research at atomic resolution using conventional electron microscopes for the measurement of amplitudes and phases

1970 • 78 citations

Analysis of photographic emulsions for electron microscopy of two-dimensional crystalline specimens

1982 • 77 citations

Distribution of RNA and protein in crystalline eukaryotic ribosomes

1982 • 77 citations

Automatic selection of molecular images from electron micrographs

1983 • 75 citations

Detection of objects in quantum-noise-limited images

1982 • 70 citations

Reconstitution of molecule images analysed by correspondence analysis: A tool for structural interpretation

1986 • 70 citations

Gap junction structures. IV. Asymmetric features revealed by low-irradiation microscopy.

1983 • 67 citations

Direct three-dimensional reconstruction for macromolecular complexes from electron micrographs

1983 • 65 citations

Computer processing of electron microscope images

1981 • 65 citations

Three-dimensional reconstruction and averaging of 50 S ribosomal subunits of Escherichia coli from electron micrographs

1983 • 53 citations

Representation of three‐dimensionally reconstructed objects in electron microscopy by surfaces of equal density

1984 • 49 citations

New methodologies in studies of protein configuration

1985 • 41 citations

Anwendung des Bilddifferenzverfahrens auf die Untersuchung von Strukturänderungen dünner Kohlefolien bei Elektronenbestrahlung

1970 • 41 citations

Computer-averaged views of the 70 S monosome from Escherichia coli

1986 • 35 citations

Eine verbesserte Drehkorrelationsmethode für die Strukturbestimmung biologischer Makromoleküle durch Mittelung elektronenmikroskopischer Bilder

1980 • 34 citations

Ribosome Evolution: The Structural Bases of Protein Synthesis in Archaebacteria, Eubacteria, and Eukaryotes

1983 • 32 citations

Averages of glutamine synthetase molecules as obtained with various stain and electron dose conditions

1980 • 30 citations

Use of nonlinear mapping in multivariate image analysis of molecule projections

1985 • 26 citations

Stereographic representation of three-dimensional density distributions

1983 • 23 citations

Three-dimensional crystals of ribosomal particles

1984 • 20 citations

Automatic selection of molecular images from dark field electron micrographs

1986 • 14 citations

A New Method for Three‐Dimensional Reconstruction of Single Macromolecules Using Low‐Dose Electron Micrographs^a

1986 • 11 citations

Localization of lipoyl-bearing domains in the .alpha.-ketoglutarate dehydrogenase multienzyme complex

1984 • 10 citations

A Computational Critique of an Algorithm for Image Enhancement in Bright Field Electron Microscopy

1979 • 9 citations

Statistical significance of molecule projections by single particle averaging

1984 • 8 citations