Secondary and Tertiary Structure Changes of Reconstituted P-glycoprotein

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Internal Reflection Spectroscopy

1968 • 1,758 citations

Internal Reflection Spectroscopy

1967 • 1,471 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Secondary structure and dosage of soluble and membrane proteins by attenuated total reflection Fourier‐transform infrared spectroscopy on hydrated films

1990 • 526 citations

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases

1988 • 480 citations

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1991 • 447 citations

Determination of Soluble and Membrane Protein Structure by Fourier Transform Infrared Spectroscopy

1994 • 421 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1995 • 362 citations

ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance

1993 • 290 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1995 • 226 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Multidrug Resistance

1991 • 207 citations

Function and Regulation of the Human Multidrug Resistance Gene

1992 • 186 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Secondary Structure of Diphtheria Toxin and Its Fragments Interacting with acidic Liposomes Studied by Polarized Infrared Spectroscopy

1989 • 134 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Photoaffinity substrates for P-glycoprotein

1992 • 105 citations

Tertiary conformational changes of the Neurospora crassa plasma membrane H(+)-ATPase monitored by hydrogen/deuterium exchange kinetics. A Fourier transformed infrared spectroscopy approach.

1994 • 82 citations

Secondary structure and orientation of the amphipathic peptide GALA in lipid structures

1991 • 69 citations

Tertiary stability of native and methionine-80 modified cytochrome c detected by proton-deuterium exchange using online Fourier transform infrared spectroscopy

1995 • 65 citations

Conformational changes of the Neurospora plasma membrane H+ATPase during its catalytic cycle.

1982 • 63 citations

Secondary structure of the particle associating domain of apolipoprotein B-100 in low-density lipoprotein by attenuated total reflection infrared spectroscopy

1993 • 46 citations

Sequence and Structure of the Membrane-Associated Peptide of Glycophorin A

1994 • 46 citations

Fourier Transform Infrared Spectroscopy Study of the Secondary Structure of the Reconstituted Neurospora crassa Plasma Membrane H+-ATPase and of Its Membrane-associated Proteolytic Peptides

1995 • 33 citations

The topology of the S protein in the yeast-derived hepatitis B surface antigen particles.

1994 • 30 citations