Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

1992 • 688 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

1986 • 586 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers.

1989 • 271 citations

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

1990 • 259 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo

1989 • 151 citations

Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells

1991 • 111 citations

Internalization and Processing of Bacillus anthracis Lethal Toxin by Toxin-sensitive and -resistant Cells

1989 • 110 citations

Anthrax toxin protective antigen: low‐pH‐induced hydrophobicity and channel formation in liposomes

1991 • 91 citations

Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.

1991 • 83 citations

Calcium is required for the expression of anthrax lethal toxin activity in the macrophagelike cell line J774A.1

1989 • 80 citations

Electron microscopic immunocytochemical localization of intracellular antigens in cultured cells: The EGS and ferritin bridge procedures

1980 • 63 citations

Quantitative Assay for Crude Anthrax Toxins

1965 • 47 citations

Purification of the Third Factor of Anthrax Toxin

1962 • 47 citations

Production in vitro of the Toxin of Bacillus anthracis Previously Recognized in vivo

1958 • 43 citations

[13] Purification and characterization of adenylyl cyclase from Bacillus anthracis

1991 • 37 citations

Specific cleavage of diphtheria toxin by human urokinase

1988 • 14 citations

Differential sensitivity of reticulocytes to nicked and unnicked diphtheria toxin

1982 • 9 citations

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