Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular.

Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo

1987 • 237 citations

cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.

1987 • 181 citations

Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.

1981 • 173 citations

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

1987 • 149 citations

Poly(ADP-ribosylation) of a DNA topoisomerase.

1983 • 145 citations

Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation

1988 • 131 citations

Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.

1987 • 127 citations

Enzyme-bound early product of purified poly(ADP-ribose) polymerase

1977 • 123 citations

Poly(ADP‐ribose) polymerase is a zinc metalloenzyme

1984 • 120 citations

Inhibition of DNA polymerase α, DNA polymerase β, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro

1985 • 111 citations

Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity

1991 • 98 citations

Purification and characterization of the major nonhistone protein acceptor for poly(adenosine diphosphate ribose) in HeLa cell nuclei

1980 • 95 citations

Poly(ADP-ribosylated) histones in chromatin replication.

1990 • 81 citations

Macromolecular association of ADP-ribosyltransferase and its correlation with enzymic activity

1990 • 79 citations

High Resolution Fractionation and Characterization of ADP-Ribose Polymers

1993 • 79 citations

Sequential ADP‐ribosylation pattern of nucleosomal histones

1985 • 77 citations

Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells

1987 • 65 citations

Reconstitution and poly(ADP-ribosyl)ation of proteolytically fragmented poly(ADP-ribose) synthetase.

1986 • 57 citations

Poly ADP-Ribosylation of Proteins

1989 • 56 citations

Evaluation of immobilized boronates for studies of adenine and pyridine nucleotide metabolism

1983 • 55 citations

Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.

1987 • 51 citations

Relationship between nicotinamide adenine dinucleotide concentration and in vitro synthesis of poly(adenosine diphosphate ribose) on purified nucleosomes

1980 • 50 citations

Characterization of a putative poly(adenosine diphosphate ribose)-chromatin complex

1980 • 43 citations

Mechanisms of poly(ADP‐ribose) polymerase catalysis; mono‐ADP‐ribosylation of poly(ADP‐ribose) polymerase at nanomolar concentrations of NAD

1986 • 41 citations

3′-Deoxy-NAD+ as a substrate for poly(ADP-ribose)polymerase and the reaction mechanism of poly(ADP-ribose) elongation.

1988 • 37 citations

Direction of elongation of poly(ADP-ribose) chains. Addition of residues at the polymerase-proximal terminus.

1987 • 31 citations

Two Proteolytic Degradation Products of Calf‐Thymus Poly(ADP‐ribose) Polymerase Are Efficient ADP‐ribose Acceptors

1983 • 27 citations

Poly ADP-ribose polymerase: Self-ADP-ribosylation, the stimulation by DNA, and the effects on nucleosome formation and stability

1979 • 23 citations

Reaction mechanism for automodification of poly(ADP-ribos synthetase

1987 • 20 citations

Mono(ADP-ribosyl)ation of poly(ADP-ribose)polymerase by cholera toxin

1991 • 7 citations

Effect of hepatocyte culture conditions on their content of nicotinamide coenzymes

1980 • 4 citations