Fusions of Human Ovarian Carcinoma Cells with Autologous or Allogeneic Dendritic Cells Induce Antitumor Immunity

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Cancer statistics, 1999

1999 • 3,154 citations

A Radioimmunoassay Using a Monoclonal Antibody to Monitor the Course of Epithelial Ovarian Cancer

1983 • 2,102 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

The CA 125 tumour-associated antigen: a review of the literature

1989 • 931 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

1984 • 583 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA

1998 • 403 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 301 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens

1999 • 239 citations

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells

1998 • 239 citations

Eliciting T Cell Immunity Against Poorly Immunogenic Tumors by Immunization with Dendritic Cell-Tumor Fusion Vaccines

1998 • 236 citations

The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial Tumors

1998 • 235 citations

A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines.

1991 • 229 citations

Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts

1997 • 209 citations

Elevation of Multiple Serum Markers in Patients With Stage I Ovarian Cancer

1993 • 198 citations

Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection.

1998 • 179 citations

Identification of New HER2/neu-Derived Peptide Epitopes That Can Elicit Specific CTL Against Autologous and Allogeneic Carcinomas and Melanomas

1999 • 176 citations

Cutting Edge: Physical Interaction Between Dendritic Cells and Tumor Cells Results in an Immunogen That Induces Protective and Therapeutic Tumor Rejection

1998 • 141 citations

Expression of MUC-1 Epitopes on Normal Bone Marrow: Implications for the Detection of Micrometastatic Tumor Cells

1999 • 126 citations

Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1).

1996 • 121 citations

Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells

1997 • 114 citations

Isolation and characterization of ovarian cancer antigen CA 125 using a new monoclonal antibody (VK-8): identification as a mucin-type molecule

1997 • 98 citations

The HER2/neu‐derived peptide p654–662 is a tumor‐associated antigen in human pancreatic cancer recognized by cytotoxic T lymphocytes

1997 • 90 citations

Serum levels of HER-2neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer

1993 • 84 citations

More than 15 Years of CA 125: What is Known about the Antigen, Its Structure and Its Function

1998 • 80 citations

Dendritic Cells Transduced with an Adenovirus Vector Encoding Epstein-Barr Virus Latent Membrane Protein 2B: a New Modality for Vaccination

1999 • 79 citations

Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity

1998 • 70 citations

Ovarian cancer-associated lymphocyte recognition of folate binding protein peptides

1998 • 53 citations

p73 competes with p53 and attenuates its response in a human ovarian cancer cell line

2000 • 52 citations

Immunological Responses to the Tumor-Associated Antigen CA15 in Patients with Advanced Ovarian Cancer Induced by the Murine Monoclonal Anti-idiotype Vaccine ACA125

1997 • 51 citations

Biological therapy of ovarian cancer: current directions.

1998 • 50 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 49 citations

Prognostic Significance of p53 and p21waf1/cip1 Immunoreactivity in Epithelial Cancers of the Ovary

1999 • 43 citations

Characterization of antitumor immunization to a defined melanoma antigen using genetically engineered murine dendritic cells

1999 • 43 citations

Human Dendritic Cells, Pulsed with either Melanoma Tumor Cell Lysates or the gp100 Peptide(280-288), Induce Pairs of T-Cell Cultures with Similar Phenotype and Lytic Activity

1998 • 42 citations

Changes in an HER-2 Peptide Upregulating HLA-A2 Expression Affect Both Conformational Epitopes and CTL Recognition

1995 • 36 citations

Expression of mucins and cytokeratins in ovarian cancer cell lines

1999 • 33 citations

BRCA 1 and 2--A Genetic Link to Familial Breast and Ovarian Cancer.

1997 • 30 citations

p53 Autoantibodies in Patients with Primary Ovarian Cancer Are Associated with Higher Age, Advanced Stage and a Higher Proportion of p53-Positive Tumor Cells

1999 • 22 citations

Antitumor protection using murine dendritic cells pulsed with acid-eluted peptides from in vivo grown tumors of different immunogenicities.

1999 • 21 citations

The immunobiology and immunotherapy of ovarian cancer.

1991 • 19 citations

New mechanism of BRCA-1 mutation by deletion/insertion at the same nucleotide position in three unrelated French breast/ovarian cancer families

1998 • 16 citations

[Monoclonal anti-idiotype antibodies in immunotherapy of ovarian carcinoma (MAb ACA125) and breast carcinoma (MAb ACA14C5)].

1999 • 12 citations

Immune directed therapy for ovarian carcinoma

1999 • 6 citations