When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation

1993 • 780 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

1994 • 730 citations

Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity

1994 • 713 citations

Two components of long-term potentiation induced by different patterns of afferent activation

1990 • 704 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

1997 • 631 citations

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice

1994 • 607 citations

The elemental principles of calcium signaling

1995 • 455 citations

Ca2+ Signaling Requirements for Long-Term Depression in the Hippocampus

1996 • 442 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

1994 • 405 citations

Synaptic plasticity in the hippocampus

1979 • 357 citations

Protein kinase C modulation of NMDA currents: an important link for LTP induction

1992 • 350 citations

Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation

1992 • 258 citations

Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells

1992 • 239 citations

Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors.

1993 • 226 citations

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

1988 • 210 citations

Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation

1995 • 197 citations

Postsynaptic Levels of [Ca2+]i Needed to Trigger LTD and LTP

1996 • 194 citations

MCPG Antagonizes Metabotropic Glutamate Receptors but not Long‐term Potentiation in the Hippocampus

1994 • 166 citations

Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability

1995 • 159 citations

Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices

1992 • 159 citations

Metabotropic glutamate receptor activation induces calcium waves within hippocampal dendrites

1994 • 140 citations

Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning

1994 • 114 citations

(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons

1993 • 114 citations

Trans-ACPD enhances long-term potentiation in the hippocampus

1991 • 107 citations

A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1α metabotropic glutamate receptors

1997 • 107 citations

Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones

1995 • 101 citations

Structure‐activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes

1996 • 97 citations

Activation of glutamate metabotropic receptors induces long-term potentiation

1992 • 78 citations

Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.

1994 • 73 citations

Metabotropic receptor-mediated long-term potentiation in rat hippocampal slices

1991 • 71 citations

Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG

1995 • 67 citations

Thapsigargin blocks long-term potentiation induced by weak, but not strong tetanisation in rat hippocampal CA1 neurons

1995 • 62 citations

Metabotropic glutamate receptor subtype agonists facilitate long-term potentiation within a distinct time window in the dentate gyrus in vivo

1996 • 57 citations

On the mechanism of long-term potentiation induced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) in rat hippocampal slices

1995 • 54 citations

Intracellular Ca2+ stores can account for the time course of LTP induction: a model of Ca2+ dynamics in dendritic spines

1995 • 52 citations

Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice

1996 • 49 citations

Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones

1993 • 45 citations

Long-term depression in rat visual cortex is associated with a lower rise of postsynaptic calcium than long-term potentiation

1996 • 42 citations

The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate receptor antagonist MCPG on long-term potentiation

1995 • 42 citations

Metabotropic glutamate receptor antagonist, (R,S)-α-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

1995 • 41 citations

Activation of NMDA receptors in hippocampal area CA1 by low and high frequency orthodromic stimulation and their contribution to induction of long‐term potentiation

1994 • 38 citations

Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices

1994 • 34 citations

1S,3R-ACPD dose-dependently induces a slow-onset potentiation in the rat hippocampal CA1 region in vivo

1995 • 32 citations

(RS)-α-Methyl-4-carboxyphenylglycine (MCPG) does not block theta burst-induced long-term potentiation in area CA1 of rat hippocampal slices

1994 • 31 citations

Asymmetric behavioral and biochemical effects of unilateral injections of 6-hydroxydopamine into the lateral brain ventricle of the rat

1972 • 27 citations

Ca2+stores and hippocampal synaptic plasticity

1996 • 22 citations

Potentiation of synaptic transmission in the rat dentate gyrus in vitro by (S)-3,5-dihydroxyphenylglycine ((S)-DHPG)

1997 • 20 citations

Increased perinuclear Ca2+ activity evoked by metabotropic glutamate receptor activation in rat hippocampal neurones.

1995 • 18 citations

A switching role of postsynaptic calcium in the induction of long-term potentiation or long-term depression in visual cortex

1996 • 14 citations

Class I metabotropic glutamate receptor agonists do not facilitate the induction of long-term potentiation in the dentate gyrus of the rat in vitro

1995 • 7 citations