The human immunoglobulin κ genes

Sequences of proteins of immunological interest

1984 • 3,427 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNA

1987 • 575 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1980 • 402 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Evolution of human immunoglobulin kappa J region genes.

1982 • 318 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Progress in immunology V

1985 • 268 citations

A uniform deleting element mediates the loss of κ genes in human B cells

1985 • 259 citations

Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization.

1982 • 242 citations

A directory of human germ‐line V_χ segments reveals a strong bias in their usage

1994 • 220 citations

Molecular time scale for evolution

1987 • 215 citations

Two regulatory elements for immunoglobulin kappa light chain gene expression.

1984 • 197 citations

Orphons: Dispersed genetic elements derived from tandem repetitive genes of eucaryotes

1981 • 188 citations

Evolution of immunoglobulin V genes: Evidence indicating that recently duplicated human Vκ sequences have diverged by gene conversion

1983 • 165 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

Human immunoglobulin variable region genes—DNA sequences of two Vκ genes and a pseudogene

1980 • 139 citations

Expressed human immunoglobulin ϰ genes and their hypermutation

1993 • 130 citations

Human Vκ immunoglobulin gene number: Implications for the origin of antibody diversity

1981 • 111 citations

Immunoglobulin genes of different subgroups are interdigitated within the V_Klocus

1984 • 110 citations

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

1985 • 109 citations

The human VK locus

1988 • 90 citations

The human immunoglobulinx locus. Characterization of the duplicated O regions

1991 • 89 citations

Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element.

1993 • 88 citations

The human C_Kgene segment and the kappa deleting element are closely linked

1986 • 88 citations

Mouse Variable‐Region Gene Families: Complexity, Polymorphism and Use in non‐Autoimmune Responses

1992 • 87 citations

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region.

1989 • 86 citations

The immunoglobulin κ locus — or — what has been learned from looking closely at one-tenth of a percent of the human genome

1993 • 81 citations

A large section of the gene locus encoding human immunoglobulin variable regions of the Kappa type is duplicated

1985 • 80 citations

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous.

1991 • 75 citations

A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments

1980 • 75 citations

Physical map of the human immunoglobulin K locus and its implications for the mechanisms of V^K–J^Krearrangement

1987 • 72 citations

The V_ϰ gene repertoire in the human germ line

1990 • 70 citations

Dispersed human immunoglobulin κ light-chain genes

1986 • 69 citations

The V_χ genes of the L regions and the repertoire of V_χ gene sequences in the human germ line

1993 • 62 citations

REVIEW

1993 • 62 citations

The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms.

1988 • 61 citations

Polymerase chain reaction-based genotyping for allotypic markers of immunoglobulin kappa shows allelic association of Km with kappa variable segment

1992 • 57 citations

An apparently common mechanism of generating antibody diversity: Length variation of the VL-JL junction

1994 • 51 citations

Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-C kappa and V kappa transcription.

1991 • 51 citations

The human immunoglobulin x locus. Characterization of the duplicated A regions

1992 • 49 citations

The Human Immunoglobulin κ Locus Consists of Two Copies That Are Organized in Opposite Polarity

1993 • 49 citations

Linking of the human immunoglobulin V_KJ_KC_Kregions by chromosomal walking

1987 • 49 citations

N segment insertion and region-directed somatic hypermutation in a Kappa gene of a t(2;8) chromosomal translocation

1987 • 45 citations

Somatic Mutation: From the dark zone to the light

1994 • 45 citations

Megabase inversions in the human genome as physiological events

1990 • 42 citations

Somatic mutation and memory

1993 • 42 citations

Polymorphisms and haplotypes in the human immunoglobulin x locus

1991 • 41 citations

Characterization of the Human Immunoglobulin Kappa Gene 3' Enhancer: Functional Importance of Three Motifs That Demonstrate B-Cell-Specific In Vivo Footprints

1992 • 41 citations

A physical map and analysis of the murine Cχ-RS region show the presence of a conserved element

1990 • 35 citations

Comparative mapping of DNA probes derived from the Vκ immunoglobulin gene regions on human and great ape chromosomes by fluorescence in situ hybridization

1995 • 34 citations

A common sequence motif near nonhomologous recombination breakpoints involving Ig sequences.

1993 • 33 citations

The immunoglobulin κ locus of primates

1995 • 32 citations

The Jκ proximal region of the human K locus contains three uncommon Vκ genes which are arranged in opposite transcriptional polarities

1988 • 32 citations

The Human Antibody V Region Repertoire to the Type B Capsular Polysaccharide of Haemophilus influenzae

1992 • 31 citations

Evolutionary Tinkering in Gene Expression

1989 • 30 citations

Human Immunoglobulin κ Gene Enhancer: Chromatin Structure Analysis at High Resolution

1987 • 30 citations

Ongoing V_x−J_x recombination after formation of a productiveV_x−J_x coding joint

1992 • 30 citations

The immunoglobulin ? locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals

1993 • 30 citations

Transposition of human immunoglobulin V kappa genes within the same chromosome and the mechanism of their amplification.

1990 • 30 citations

The human immunoglobulin χ locus. Characterization of the partially duplicated L regions

1993 • 29 citations

The Human Immunoglobulin ϰ Locus: Pseudogenes, Unique and Repetitive Sequences

1994 • 29 citations

Tissue specific gene expression

1990 • 29 citations

Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprints.

1992 • 28 citations

Nucleotide sequence of the intron of the germline humanximmunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer

1992 • 26 citations

The Human Immunoglobulin ϰ Locus and Some of its Acrobatics

1990 • 24 citations

Structural features of transposed human V_Kgenes and implications for the mechanism of their transpositions

1990 • 24 citations

A human immunoglobulin kappa orphon without sequence defects may be the product of a pericentric inversion

1990 • 20 citations

Localization, analysis and evolution of transposed human immunoglobulin Vκ genes

1988 • 19 citations

Two Unusual Human Immunoglobulin V_κGenes

1988 • 19 citations

Functional modularity in the SP6xpromoter

1991 • 18 citations

Human immunoglobulin kappa gene enhancer: chromatin structure analysis at high resolution.

1987 • 18 citations

Pentadecamer-Binding Proteins: Definition of Two Independent Protein-Binding Sites Needed for Functional Activity

1995 • 16 citations

Homozygosity for inversion (2)(p12q14)

1993 • 16 citations

Searching for non-Vκ transcripts from the human immunoglobulin κ locus

1995 • 16 citations

The Z family, a group of transposed human immunoglobulin Vκ genes

1988 • 16 citations

Mapping Immunoglobulin Gene-Related DNA Probes to the Central Region of Normal and Pericentrically Inverted Human Chromosome 2

1993 • 16 citations

Of Orphons and UHOs. Delimitation of the Germline Repertoire of Human Immunoglobulin ϰ Genes

1992 • 13 citations

Notes on individual sequence variation in humans: immunoglobulin kappa light chain.

1994 • 13 citations

The V-J-Intergenic Region of the HumanϰLocus

1989 • 12 citations

Human immunoglobulin variable region genes: V ? polymorphisms suggest variation in V-gene repertoires

1987 • 12 citations

The CD8α Locus Is Located on the Telomere Side of the Immunoglobulin κ Locus at a Distance of 2 Mb

1993 • 11 citations

Transposed human immunoglobulin Vκ gene regions carry clusters of conserved sequence elements

1988 • 11 citations

Evolution of a Group of Transposed Human V_ϰGenes

1990 • 10 citations

SacI RFLP recognized by a human immunoglobulin kappa light chain constant region probe

1987 • 10 citations

An ACCC-containing protein-binding sequence in the neighbourhood of the decanucleotide recognition site of the immunoglobulin gene promoter

1988 • 8 citations

Structure of extrachromosomal circular DNAs generated by immunoglobulin light chain gene rearrangements

1991 • 8 citations

Polymorphisms in the VK gene patterns of rheumatoid arthritis patients and control individuals.

1990 • 6 citations

A Potentially Functional Vκ Gene at a Distance of 1.5 Mb from the Immunoglobulin κ Locus

1994 • 5 citations

Human Immunoglobulin Genes of the ϰ Type. The Long-Range Map of an OrphonV_ϰ<b />Gene Region

1992 • 2 citations

Deleted Work

1955 • 0 citations