Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

The essentials of DNA methylation

1992 • 960 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

1996 • 587 citations

DNA methylation errors and cancer.

1996 • 405 citations

Complex structure and regulation of the P16 (MTS1) locus.

1995 • 402 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

A novel p16INK4A transcript.

1995 • 348 citations

Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.

1995 • 261 citations

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

1994 • 237 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

1996 • 193 citations

Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.

1995 • 184 citations

p16 gene alterations in nasopharyngeal carcinoma.

1995 • 139 citations

Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.

1996 • 138 citations

p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro.

1996 • 99 citations

Mutational effects on the p16INK4a tumor suppressor protein.

1995 • 96 citations

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma

1994 • 95 citations

Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia

1995 • 89 citations

Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract.

1995 • 81 citations

Mutations and polymorphisms in thep53, p21 andp16 genes in oral carcinomas of Indian betel quid chewers

1996 • 69 citations

Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage

1996 • 66 citations

Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer.

1996 • 58 citations

Mutational Analysis of CDKN2 (CDK4I/MTS1) Gene in Tissues and Cell Lines of Human Prostate Cancer

1995 • 58 citations

No point mutation but decreased expression of the p16/MTS1 tumor suppressor gene in nasopharyngeal carcinomas.

1995 • 57 citations

Demethylation of repetitive DNA sequences in neuroblastoma

1996 • 56 citations

Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions

1996 • 53 citations

Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.

1995 • 53 citations

Methylated CpG points identified withinMAGE-1 promoter are involved in gene repression

1996 • 50 citations

p16INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression.

1996 • 40 citations

p16 inhibition of transformed and primary squamous epithelial cells.

1996 • 37 citations

Loh and mutation analysis of CDKN2 in primary human ovarian cancers

1995 • 35 citations

Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines

1995 • 29 citations

Homozygous deletions of p16INK4 occur frequently in bilharziasis-associated bladder cancer

1996 • 28 citations

Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers.

1996 • 26 citations

Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers

1995 • 20 citations

A novel clonality assay for the mouse: Application to hepatocellular carcinomas induced with diethylnitrosamine

1996 • 9 citations