p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma
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Abstract
References (33)
Molecular Cloning: A Laboratory Manual
2001 • 133,517 citations
Molecular cloning: A laboratory manual
1990 • 85,659 citations
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1993 • 3,680 citations
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
1995 • 2,000 citations
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1995 • 894 citations
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.
1995 • 713 citations
Mutations and altered expression of p16INK4 in human cancer.
1994 • 547 citations
Growth suppression by p16ink4 requires functional retinoblastoma protein.
1995 • 441 citations
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.
1994 • 370 citations
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
1993 • 367 citations
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.
1995 • 355 citations
Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.
1994 • 345 citations
Rb and p16INK4a expression in resected non-small cell lung tumors.
1996 • 236 citations
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
1994 • 231 citations
p53 alteration in gastric precancerous lesions.
1994 • 229 citations
Structure of the human retinoblastoma gene.
1989 • 193 citations
Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins
1996 • 176 citations
Compilation of somatic mutations of theCDKN2 gene in human cancers: Non-random distribution of base substitutions
1996 • 174 citations
Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression.
1995 • 172 citations
Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study
1996 • 128 citations
Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma.
1996 • 92 citations
Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level.
1991 • 88 citations
Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract.
1995 • 81 citations
MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines.
1995 • 80 citations
Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers
1995 • 76 citations
Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti‐RB antibodies
1994 • 66 citations
Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas
1996 • 50 citations
Wild-type and mutant retinoblastoma protein in paraffin sections.
1996 • 48 citations
Low frequency ofp16/CDKN2 gene mutations in esophageal carcinomas
1996 • 45 citations
Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas
1993 • 40 citations
Immunohistochemical studies on Waf1p21, p16, pRb and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in northern China
1997 • 38 citations
p53 alterations but no human papillomavirus infection in preinvasive and advanced squamous esophageal cancer in Italy.
1997 • 28 citations
Genomic DNA and messenger rna expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines
1995 • 16 citations