TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

Frequent p53 mutations in head and neck cancer.

1992 • 287 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

Overexpression of p53 Protein in Squamous Cell Carcinomas of Head and Neck Without Apparent Gene Mutations

1994 • 74 citations

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

1993 • 49 citations

Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture)

1993 • 17 citations

FRAMESHIFT AND NONSENSE P53 MUTATIONS IN SQUAMOUS-CELL CARCINOMA OF HEAD AND NECK - NON-REACTIVITY WITH 3 ANTI-P53 MONOCLONAL-ANTIBODIES

1994 • 13 citations

Cyclin E enhances P53‐mediated transactivation

1993 • 11 citations