Increased phosphorylation of the amino-terminal domain of the low molecular weight neurofilament subunit in okadaic acid-treated neurons

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

1975 • 937 citations

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1993 • 490 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

X-ray intensifying screens greatly enhance the detection by autoradiography of the radioactive isotopes 32P and 125I

1978 • 419 citations

[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

1988 • 418 citations

Multiple phosphorylation sites in mammalian neurofilament polypeptides.

1982 • 381 citations

Neurofilament phosphorylation: a new look at regulation and function

1991 • 309 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

Phosphorylation of desmin in vitro inhibits formation of intermediate filaments; identification of three kinase A sites in the aminoterminal head domain.

1988 • 224 citations

A new method for partial peptide mapping using N-chlorosuccinimide/urea and peptide silver staining in sodium dodecyl sulfate-polyacrylamide gels

1982 • 219 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Cytoskeletal integrity in interphase cells requires protein phosphatase activity.

1992 • 174 citations

[40] Use of okadaic acid to inhibit protein phosphatases in intact cells

1991 • 162 citations

Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.

1990 • 155 citations

Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.

1991 • 140 citations

Complete amino acid sequence and in vitro expression of rat NF-M, the middle molecular weight neurofilament protein.

1987 • 134 citations

Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.

1990 • 126 citations

Assembly and exchange of intermediate filament proteins of neurons: neurofilaments are dynamic structures.

1989 • 124 citations

In Vivo Phosphorylation of Distinct Domains of the 70-Kilodalton Neurofilament Subunit Involves Different Protein Kinases

1989 • 109 citations

O-phosphoserine content of intermediate filament subunits

1982 • 109 citations

Dynamics of the neuronal intermediate filaments.

1993 • 103 citations

The regulation of intermediate filament reorganization in mitosis.

1991 • 103 citations

Two different protein kinases act on a different time schedule as glial filament kinases during mitosis.

1992 • 102 citations

A significant soluble keratin fraction in ‘simple’ epithelial cells Lack of an apparent phosphorylation and glycosylation role in keratin solubility

1993 • 101 citations

Phosphorylation in vitro of vimentin by protein kinases A and C is restricted to the head domain

1989 • 99 citations

Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1.

1991 • 92 citations

Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells.

1989 • 89 citations

Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form

1990 • 88 citations

Phosphorylation of bovine neurofilament proteins by protein kinase FA (glycogen synthase kinase 3)

1991 • 86 citations

Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro

1990 • 81 citations

Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cells.

1987 • 77 citations

Dephosphorylation of phosphoproteins and synthetic phosphopeptides. Study of the specificity of the polycation-stimulated and MgATP-dependent phosphorylase phosphatases.

1987 • 74 citations

Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro

1990 • 73 citations

p34cdc2 phosphorylation sites in histone H1 are dephosphorylated by protein phosphatase 2A1

1991 • 70 citations

Characteristics of the protein kinase activity associated with rat neurofilament preparations

1983 • 69 citations

The protein phosphatase inhibitor okadaic acid increases axonal neurofilaments and neurite caliber, and decreases axonal microtubules in NB2a/d1 Cells

1993 • 69 citations

Phosphorylation of neurofilament proteins by protein kinase C

1988 • 67 citations

Phosphorylation of neurofilament proteins by endogenous calcium/calmodulin-dependent protein kinase

1985 • 55 citations

Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons

1992 • 50 citations

Resolution and purification of a neurofilament-specific kinase.

1989 • 45 citations

Characterization of neurofilament-associated protein kinase activities from bovine spinal cord

1990 • 38 citations

A rat brain protein kinase phosphorylating specifically neurofilaments

1983 • 36 citations

Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels

1987 • 35 citations

Dephosphorylation of Microtubule-Binding Sites at the Neurofilament-H Tail Domain by Alkaline, Acid, and Protein Phosphatases1

1993 • 30 citations

Effects of phorbol esters on cytoskeletal proteins in cultured bovine chromaffin cells: induction of neurofilament phosphorylation and reorganization of actin.

1990 • 29 citations

Properties of several protein kinases that copurify with rat spinal cord neurofilaments

1989 • 28 citations

Phosphatase activity against neurofilament proteins from bovine spinal cord: Effect of aluminium and neuropsychoactive drugs

1992 • 15 citations

Applications of chemical cleavage procedures to the peptide mapping of neurofilament triplet protein bands in sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1986 • 15 citations

Neurofilament Phosphorylation in Cultured Bovine Adrenal Chromaffin Cells Is Stimulated by Phorbol Ester

1989 • 12 citations