TRP channels in airway smooth muscle as therapeutic targets
Data up to Jan 2025
Total Citations Per Year
Abstract
References (69)
Calcium's Role in Mechanotransduction during Muscle Development
2014 • 14,293 citations
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
2003 • 7,170 citations
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
1999 • 1,456 citations
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
2000 • 1,348 citations
Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma
1985 • 1,315 citations
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
2000 • 982 citations
LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death
2002 • 794 citations
Abnormal osmotic regulation in trpv4 -/- mice
2003 • 760 citations
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
2001 • 737 citations
Subunit composition of mammalian transient receptor potential channels in living cells
2002 • 729 citations
Airway remodeling in asthma
1999 • 708 citations
TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization
2002 • 700 citations
TRPC1, a human homolog of a Drosophila store-operated channel.
1995 • 623 citations
The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α 1 -Adrenoceptor–Activated Ca 2+ -Permeable Cation Channel
2001 • 596 citations
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
2002 • 595 citations
Rapid vesicular translocation and insertion of TRP channels
2004 • 535 citations
Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries
2002 • 487 citations
The diversity in the vanilloid (TRPV) receptor family of ion channels
2002 • 485 citations
TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes
2003 • 481 citations
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I
1999 • 473 citations
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension
2004 • 414 citations
TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel
2003 • 386 citations
On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins
1996 • 378 citations
Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3
2003 • 345 citations
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression
2003 • 333 citations
Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline.
1981 • 318 citations
Selective Association of TRPC Channel Subunits in Rat Brain Synaptosomes
2002 • 314 citations
Receptor-activated Ca2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca2+ signalling requirements
1999 • 295 citations
The TRPM ion channel subfamily: molecular, biophysical and functional features
2004 • 272 citations
Receptor‐activated calcium influx in human airway smooth muscle cells.
1991 • 258 citations
Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain
1998 • 255 citations
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels
2003 • 251 citations
Non‐selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP
2004 • 245 citations
New drugs for asthma
2004 • 196 citations
Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma.
1983 • 190 citations
Functional TRPV4 channels are expressed in human airway smooth muscle cells
2004 • 173 citations
Current understanding of mammalian TRP homologues
2002 • 158 citations
Role of capacitative Ca2+entry in bronchial contraction and remodeling
2002 • 139 citations
TRPC1 store-operated cationic channel subunit
2003 • 133 citations
Non-specific broncho-reactivity obtained with an ultrasonic aerosol of distilled water.
1980 • 122 citations
Functional expression of TrpC1: a human homologue of the Drosophila Trp channel
1998 • 109 citations
Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis
1995 • 109 citations
Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line
2002 • 108 citations
Calcium and TRP Channels in Pulmonary Vascular Smooth Muscle Cell Proliferation
2004 • 107 citations
Store-operated Ca2+entry in porcine airway smooth muscle
2004 • 101 citations
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels
2005 • 99 citations
20-Hydroxyeicosatetraenoic Acid (20-HETE) Activates Mouse TRPC6 Channels Expressed in HEK293 Cells
2003 • 96 citations
Expression of Transient Receptor Potential C6 and Related Transient Receptor Potential Family Members in Human Airway Smooth Muscle and Lung Tissue
2003 • 93 citations
Clinical studies with calcium antagonists in asthma.
1985 • 89 citations
Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Proliferation and Cell Adhesion Molecule Expression
1998 • 86 citations
Calcium currents in isolated canine airway smooth muscle cells
1988 • 78 citations
Dihydropyridine-sensitive single calcium channels in airway smooth muscle cells
1990 • 73 citations
Receptor-activated Ca influx in human airway smooth muscle: use of Ca imaging and perforated patch-clamp techniques
1993 • 73 citations
Regulation of Capacitative and Noncapacitative Receptor-Operated Ca2 + Entry by Rho-Kinase in Tracheal Smooth Muscle
2002 • 67 citations
The Vanilloid Receptor Family of Calcium-Permeable Channels: Molecular Integrators of Microenvironmental Stimuli
2003 • 60 citations
Evidence for the expression of transient receptor potential proteins in guinea pig airway smooth muscle cells
2003 • 47 citations
Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent
2004 • 44 citations
Mechanisms of leukotriene D4‐induced constriction in human small bronchioles
2001 • 42 citations
Roles of Ca2+ influx and intracellular Ca2+ release in agonist-induced contractions in guinea pig trachea
1994 • 40 citations
A possible role for TRPV4 receptors in asthma
2004 • 39 citations
20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle
2003 • 34 citations
Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle
2004 • 30 citations
The effect of non-isotonic solutions on human isolated airway smooth muscle
1987 • 28 citations
Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.
1998 • 24 citations
Endothelin-1 Is a Potent Activator of Nonselective Cation Currents in Human Bronchial Smooth Muscle Cells
2000 • 23 citations
EFFECTS OF VARIOUS PHARMACOLOGICAL AGENTS ON ISOLATED HUMAN BRONCHIAL AND PULMONARY ARTERIAL AND VENOUS MUSCLE PREPARATIONS CONTRACTED BY LEUKOTRIENE D4
1987 • 21 citations
Inhibition of smooth-muscle myosin-light-chain phosphatase by Ruthenium Red
2000 • 19 citations
Calcium, Calcium Channel Blockade and Airways Function
1986 • 17 citations
Differential effects of nifedipine and diltiazem on methacholine-induced bronchospasm in allergic asthma.
1989 • 6 citations