The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities

Escherichia coli and Salmonella :cellular and molecular biology

1996 • 8,124 citations

The Complete Genome Sequence of Escherichia coli K-12

1997 • 7,325 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

Exploring the new world of the genome with DNA microarrays

1999 • 2,454 citations

The control of flux.

1973 • 1,381 citations

Understanding the control of metabolism

1997 • 1,265 citations

Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110

1994 • 1,061 citations

Global Transposon Mutagenesis and a Minimal Mycoplasma Genome

1999 • 918 citations

Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use

1994 • 914 citations

Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization

1997 • 858 citations

E-CELL: software environment for whole-cell simulation.

1999 • 781 citations

Biochemical systems analysis

1969 • 743 citations

Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering

1999 • 673 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

Genome-wide expression profiling in Escherichia coli K-12

1999 • 584 citations

Systems Properties of the Haemophilus influenzaeRd Metabolic Genotype

1999 • 405 citations

Metabolic Pathway Analysis: Basic Concepts and Scientific Applications in the Post-genomic Era

1999 • 389 citations

Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K‐12

1997 • 341 citations

Flux analysis of underdetermined metabolic networks: the quest for the missing constraints

1997 • 338 citations

Mathematical Modeling and Analysis in Biochemical Engineering: Past Accomplishments and Future Opportunities

1998 • 326 citations

Stoichiometric model ofEscherichia coli metabolism: Incorporation of growth-rate dependent biomass composition and mechanistic energy requirements

1997 • 322 citations

The EcoCyc and MetaCyc databases

2000 • 295 citations

Computation with the KEGG pathway database

1998 • 279 citations

Metabolic Capabilities of Escherichia coli: I. Synthesis of Biosynthetic Precursors and Cofactors

1993 • 279 citations

Investigation of bacterial growth on mixed substrates: Experimental evaluation of cybernetic models

1986 • 266 citations

Metabolic flux analysis of hybridoma cells in different culture media using mass balances

1996 • 261 citations

Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli

1995 • 234 citations

Metabolic Capabilities of Escherichia coli II. Optimal Growth Patterns

1993 • 232 citations

Pathway analysis, engineering, and physiological considerations for redirecting central metabolism

1996 • 185 citations

Energetic efficiency of Escherichia coli: effects of mutations in components of the aerobic respiratory chain

1993 • 181 citations

Characterization of the Essential Gene glmM Encoding Phosphoglucosamine Mutase in Escherichia coli

1996 • 175 citations

Integrated pathway–genome databases and their role in drug discovery

1999 • 161 citations

Carbon and energy metabolism of atp mutants of Escherichia coli

1992 • 146 citations

Promoters of the atp operon coding for the membrane-bound ATP synthase of Escherichia coli Mapped by Tn 10 insertion mutations

1982 • 127 citations

Requirement for the Proton‐Pumping NADH Dehydrogenase I of Escherichia Coli in Respiration of NADH to Fumarate and Its Bioenergetic Implications

1997 • 125 citations

MPW: the Metabolic Pathways Database

1998 • 123 citations

Escherichia coliproteome analysis using the gene‐protein database

1997 • 113 citations

Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid.

1998 • 95 citations

Metabolic capacity ofBacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid

1998 • 88 citations

Malate Dehydrogenase Mutants in Escherichia coli K-12

1970 • 63 citations

The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase

1992 • 61 citations

Succinate Dehydrogenase-dependent Nutritional Requirement for Succinate in Mutants of Escherichia coli K12

1978 • 49 citations

Effects of an insertion mutation in a locus affecting pyridine nucleotide transhydrogenase (pnt::Tn5) on the growth of Escherichia coli

1980 • 40 citations

atp Mutants of Escherichia coli Fail To Grow on Succinate Due to a Transport Deficiency

1998 • 40 citations

Reducing complexity in metabolic networks: making metabolic meshes manageable.

1987 • 34 citations

Is the ribulose monophosphate pathway widely distributed in bacteria?

1997 • 34 citations

Synthesis of biochemical production routes

1992 • 33 citations

A mathematical model for the growth of a single cell of E. coli on a glucose/glutamine/ammonium medium

1989 • 31 citations

Phenotypic Suppression of Phosphofructokinase Mutations in Escherichia coli by Constitutive Expression of the Glyoxylate Shunt

1974 • 29 citations

A comprehensive model of human erythrocyte metabolism: extensions to include pH effects.

1990 • 26 citations

Physiological effects of the fructose-1,6-diphosphate aldolase ts8 mutation on stable RNA synthesis in Escherichia coli

1991 • 24 citations

Metabolic engineering

2000 • 14 citations