Epistasis in Polygenic Traits and the Evolution of Genetic Architecture under Stabilizing Selection

Genetics and Analysis of Quantitative Traits

2002 • 6,393 citations

QUANTITATIVE GENETIC ANALYSIS OF MULTIVARIATE EVOLUTION, APPLIED TO BRAIN:BODY SIZE ALLOMETRY

1979 • 2,334 citations

The strategy of the genes

1957 • 2,000 citations

Selection and Covariance

1970 • 1,938 citations

NATURAL SELECTION AND RANDOM GENETIC DRIFT IN PHENOTYPIC EVOLUTION

1976 • 1,625 citations

PERSPECTIVE: COMPLEX ADAPTATIONS AND THE EVOLUTION OF EVOLVABILITY

1996 • 1,550 citations

Quantitative Genetic Analysis of Multivariate Evolution, Applied to Brain: Body Size Allometry

1979 • 1,397 citations

GENETIC ASSIMILATION OF AN ACQUIRED CHARACTER

1953 • 1,123 citations

The Genetic Architecture of Quantitative Traits

2001 • 1,100 citations

Understanding quantitative genetic variation

2002 • 847 citations

The maintenance of genetic variability by mutation in a polygenic character with linked loci

1975 • 797 citations

Factors of Evolution:. The Theory of Stabilizing Selection

1950 • 773 citations

Principles for the Buffering of Genetic Variation

2001 • 708 citations

The Mathematical Theory of Selection, Recombination, and Mutation

2000 • 675 citations

EVOLUTIONARY QUANTITATIVE GENETICS: HOW LITTLE DO WE KNOW?

1989 • 657 citations

Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle

1984 • 610 citations

Neutral evolution of mutational robustness

1999 • 595 citations

Epistasis and its contribution to genetic variance components.

1995 • 530 citations

A POPULATION GENETIC THEORY OF CANALIZATION

1997 • 486 citations

PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION

1999 • 449 citations

Epistasis and the Evolutionary Process

2000 • 434 citations

Robustness against mutations in genetic networks of yeast

2000 • 412 citations

Comparing Mutational Variabilities

1996 • 409 citations

Canalization in evolutionary genetics: a stabilizing theory?

2000 • 349 citations

DOES EVOLUTIONARY PLASTICITY EVOLVE?

1996 • 309 citations

Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting

1996 • 268 citations

Adaptive landscapes, genetic distance and the evolution of quantitative characters

1987 • 258 citations

Effects of P element insertions on quantitative traits in Drosophila melanogaster.

1992 • 238 citations

Canalization: Genetic and Developmental Aspects

1991 • 224 citations

Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction

2001 • 219 citations

FITNESS SENSITIVITY AND THE CANALIZATION OF LIFE-HISTORY TRAITS

1994 • 217 citations

Dynamics of polygenic characters under selection

1990 • 195 citations

The Strategy of the Genes

2014 • 192 citations

THE EVOLUTION OF CANALIZATION AND THE BREAKING OF VON BAER'S LAWS: MODELING THE EVOLUTION OF DEVELOPMENT WITH EPISTASIS

1998 • 188 citations

Effect of Polymorphism in the Drosophila Regulatory Gene Ultrabithorax on Homeotic Stability

1996 • 174 citations

Epistasis and its consequences for the evolution of natural populations

1997 • 167 citations

THE EVOLUTION OF GENETIC CANALIZATION UNDER FLUCTUATING SELECTION

2000 • 138 citations

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

1981 • 136 citations

Canalization: A molecular genetic perspective

1997 • 134 citations

Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster

1990 • 134 citations

Properties of spontaneous mutations affecting quantitative traits

1999 • 118 citations

Genotypic variation for a quantitative character maintained under stabilizing selection without mutations: epistasis.

1989 • 75 citations

THE UNIT OF SELECTION IN DROSOPHILA MERCATORUM I. THE INTERACTION OF SELECTION AND MEIOSIS IN PARTHENOGENETIC STRAINS

1976 • 74 citations

THE EVOLUTION OF DOMINANCE: A THEORY WHOSE TIME HAS PASSED?

1997 • 65 citations

Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.

1993 • 63 citations

Genetic Variation Maintained in Multilocus Models of Additive Quantitative Traits Under Stabilizing Selection

1999 • 59 citations

Epistasis and the Mutation Load: A Measurement-Theoretical Approach

2001 • 56 citations

The Relationship Between Risk Factor Levels and Presence of Coronary Artery Calcification is Dependent on Apolipoprotein E Genotype

1999 • 52 citations

Mutation load and mutation-selection-balance in quantitative genetic traits

1994 • 49 citations

THE EVOLUTION OF DOMINANCE: A THEORY WHOSE TIME HAS PASSED?

1997 • 43 citations

The Stability of Symmetric Solutions to Polygenic Models

2000 • 39 citations

The distribution of allelic effects under mutation and selection

1990 • 29 citations

Modeling the Evolution of Genetic Architecture: A Continuum of Alleles Model with Pairwise A×A Epistasis

2000 • 26 citations

Nonequivalent Loci and the Distribution of Mutant Effects

2002 • 20 citations

Non-equivalent loci and mutation–selection balance

2003 • 7 citations