BCR-ABL: An Anti-Apoptosis Gene in Chronic Myelogenous Leukemia

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Chronic myelogenous leukemia: recent advances

1985 • 247 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 245 citations

Chronic myelogenous leukemia: recent advances

1985 • 190 citations

The CML-Specific P210bcr/ablProtein, Unlike v-abl, Does Not Transform NIH/3T3 Fibroblasts

1987 • 181 citations

The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.

1987 • 179 citations

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

1994 • 176 citations

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.

1993 • 157 citations

Differential Phosphorylation of c-Abl in Cell Cycle Determined by cdc 2 Kinase and Phosphatase Activity

1990 • 157 citations

A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product

1979 • 146 citations

Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.

1987 • 81 citations

DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.

1988 • 67 citations

Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.

1992 • 49 citations

Suppression of Giα2 enhances phospholipase C signalling

1994 • 39 citations

Normal Cellular and Transformation-Associated abl Proteins Share Common Sites fOr Protein Kinase C Phosphorylation

1987 • 35 citations

Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.

1987 • 27 citations

Philadelphia chromosome translocation.

1989 • 12 citations