Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

1995 • 505 citations

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.

1986 • 492 citations

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

1994 • 477 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.

1993 • 416 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.

1985 • 343 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

1994 • 288 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

1995 • 227 citations

Antigenic analysis of hematopoiesis. VI. Flow cytometric characterization of My-10-positive progenitor cells in normal human bone marrow.

1987 • 226 citations

Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.

1991 • 222 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

Studies of interferon as a regulator of hematopoietic cell proliferation.

1985 • 195 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro.

1984 • 180 citations

Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice

1989 • 171 citations

Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults

1994 • 169 citations

Tumor necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells.

1987 • 155 citations

Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.

1991 • 155 citations

Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

1992 • 153 citations

Measurement of serum cytokine levels in patients with myelodysplastic syndromes.

1992 • 150 citations

Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha

1994 • 137 citations

Effects on leukocytes after injection of tumor necrosis factor into healthy humans

1992 • 135 citations

Gamma-Interferon Gene Expression in the Bone Marrow of Patients with Aplastic Anemia

1994 • 133 citations

Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells.

1994 • 122 citations

Nitric oxide production by tumor targets in response to TNF: paradoxical correlation with susceptibility to TNF-mediated cytotoxicity without direct involvement in the cytotoxic mechanism

1992 • 89 citations

Interferon-gamma gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia

1992 • 77 citations

Sequence of a cDNA coding for human IRF-1

1989 • 74 citations

Interleukin 1 induction of the c-jun promoter.

1993 • 73 citations

Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells.

1994 • 67 citations

Sequence of a cDNA coding for human IRF-2

1989 • 40 citations

Recombinant human TNF-alpha: preclinical studies and results from early clinical trials.

1992 • 38 citations

Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene.

1994 • 32 citations

Induction of TNF‐α in patients with myelodysplastic syndromes undergoing treatment with interleukin‐3

1993 • 32 citations

Development of Antisense Therapeutics: Implications for Cancer Gene Therapy

1994 • 28 citations

Production of citrulline and ornithine by interferon-γ treated macrophages

1991 • 21 citations

The generation of nitric oxide participates in γIFN-induced MHC class II antigen expression by cultured astrocytoma cells

1993 • 20 citations

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