Bone Morphogenetic Protein-7 Signals Opposing Transforming Growth Factor β in Mesangial Cells

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

2003 • 1,308 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

2003 • 741 citations

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

2003 • 655 citations

Signal transduction by bone morphogenetic proteins

1998 • 528 citations

Divergence and convergence of TGF‐β/BMP signaling

2001 • 503 citations

Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

2001 • 397 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

Cross‐talk between ERK MAP kinase and Smad‐signaling pathways enhances TGF‐β dependent responses in human mesangial cells

2003 • 359 citations

Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation

2000 • 303 citations

Connective Tissue Growth Factor Gene Regulation

2003 • 301 citations

Smad6 Is a Smad1/5-induced Smad Inhibitor

2000 • 277 citations

Loss of Tubular Bone Morphogenetic Protein—7 in Diabetic Nephropathy

2001 • 233 citations

Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-β in Normal Human Osteoblastic Cells

2002 • 230 citations

Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy11Professor Robert Chevalier served as a guest editor for this paper.

2003 • 226 citations

Nucleocytoplasmic transport: Ran, beta and beyond

2001 • 226 citations

Bone Morphogenetic Protein-7 Improves Renal Fibrosis and Accelerates the Return of Renal Function

2002 • 222 citations

Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).

1996 • 189 citations

Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy

2003 • 188 citations

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

2000 • 187 citations

TGF-β1 activates MAP kinase in human mesangial cells: A possible role in collagen expression

1999 • 187 citations

Glomerular epithelial, mesangial, and endothelial cell lines from transgenic mice

1988 • 167 citations

Nucleocytoplasmic Shuttling of Smad1 Conferred by Its Nuclear Localization and Nuclear Export Signals

2001 • 114 citations

5-Fluorouracil Blocks Transforming Growth Factor-β–Induced α₂Type I Collagen Gene (COL1A2) Expression in Human Fibroblasts via c-Jun NH₂-Terminal Kinase/Activator Protein-1 Activation

2003 • 111 citations

The Transforming Activity of Ski and SnoN Is Dependent on Their Ability to Repress the Activity of Smad Proteins

2003 • 110 citations

Smad Transcriptional Corepressors in TGFβ Family Signaling

2001 • 109 citations

Smad6 Suppresses TGF-β-Induced Growth Inhibition in COLO-357 Pancreatic Cancer Cells and Is Overexpressed in Pancreatic Cancer

1999 • 109 citations

Is Smad3 a Major Player in Signal Transduction Pathways Leading to Fibrogenesis?

2001 • 106 citations

Blockade of maitotoxin-induced endothelial cell lysis by glycine and <scp>l</scp>-alanine

2003 • 81 citations

Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys

2000 • 65 citations

Two Short Segments of Smad3 Are Important for Specific Interaction of Smad3 with c-Ski and SnoN

2002 • 54 citations

Bone Morphogenetic Protein-7 Inhibits Constitutive and Interleukin-1β-Induced Monocyte Chemoattractant Protein-1 Expression in Human Mesangial Cells: Role for JNK/AP-1 Pathway

2003 • 51 citations

Smad7 is a TGF-β-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis

2000 • 43 citations

A Novel Nuclear Export Signal in Smad1 Is Essential for Its Signaling Activity

2003 • 40 citations