Activation of T Lymphocytes via Monoclonal Antibodies against Rat Cell Surface Antigens with Particular Reference to CD2 Antigen

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.

1989 • 455 citations

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages.

1985 • 353 citations

A year in the life of the immunoglobulin superfamily

1987 • 345 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

A monoclonal antibody blocking human T cell function

1980 • 239 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1987 • 220 citations

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells.

1985 • 218 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.

1988 • 173 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Suppression of human T-cell mitogenesis and E-rosette formation by the monoclonal antibody OKT11A.

1981 • 151 citations

T cell activation via CD2 [T, gp50] molecules: accessory cells are required to trigger T cell activation via CD2-D66 plus CD2-9.6/T11(1) epitopes.

1985 • 150 citations

The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

1987 • 148 citations

Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation.

1987 • 145 citations

Similarities in sequences and cellular expression between rat CD2 and CD4 antigens.

1987 • 143 citations

Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43.

1988 • 125 citations

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction

1987 • 121 citations

Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

1989 • 118 citations

Species heterogeneity in macrophage expression of the CD4 antigen.

1987 • 103 citations

The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

1989 • 101 citations

Inhibition of mixed lymphocyte response by monoclonal antibody specific for a rat T lymphocyte subset

1979 • 94 citations

A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen

1988 • 93 citations

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

1987 • 92 citations

Many cells in rat bone marrow have cell‐surface Thy‐1 antigen

1976 • 85 citations

The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids.

1987 • 83 citations

Isolation of encephalitogenic CD4+ T cell clones in the rat

1989 • 78 citations

Activation of human T4 cells by cross-linking class I MHC molecules.

1988 • 75 citations

MRC OX-52: a rat T-cell antigen.

1986 • 73 citations

A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes.

1989 • 68 citations

Stimulation and proliferation of CD4⁺ peripheral blood T lymphocytes induced by an anti‐CD4 monoclonal antibody

1988 • 68 citations

Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies.

1988 • 67 citations

Characterization of a CD3-like rat T cell surface antigen recognized by a monoclonal antibody.

1989 • 66 citations

Structural and binding analysis of a two domain extracellular CD2 molecule.

1989 • 61 citations

Purified lymphocyte function‐associated antigen‐3 and T11 target structure are active in CD2‐mediated T cell stimulation

1987 • 60 citations

Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells.

1987 • 50 citations

Effects of Lyt antibodies on T-cell functions: augmentation by anti-Lyt-1 as opposed to inhibition by anti-Lyt-2.

1981 • 45 citations

Amplification of the immune response by agonistic antibodies

1986 • 44 citations

Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities.

1988 • 40 citations

Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens

1989 • 38 citations

Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes.

1989 • 22 citations

Selective stimulation of human t lymphocyte subsets by heteroconjugates of antibodies to the t cell receptor and to subset-specific differentiation antigens

1988 • 19 citations

The autonomy of CD8+ T cells in vitro and in vivo.

1988 • 16 citations

Stable expression of the cDNA encoding the human T lymphocyte‐specific CD2 antigen in murine L cells

1988 • 11 citations