The role of the L3T4 molecule in mitogen and antigen-activated signal transduction

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

MONOCLONAL ANTIBODIES TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS

1982 • 471 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1985 • 223 citations

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.

1984 • 214 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma.

1984 • 146 citations

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

1985 • 119 citations

Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol.

1986 • 101 citations

The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells.

1986 • 98 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

1986 • 89 citations

The effect of mitogenic lectins and monoclonal antibodies on intracellular free calcium concentration in human T-lymphocytes

1984 • 80 citations

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

1986 • 78 citations

Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.

1985 • 75 citations

Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells.

1985 • 72 citations

Role of L3T4 in antigen-driven activation of a class I-specific T cell hybridoma.

1985 • 56 citations

Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytes.

1984 • 51 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IX. Role of accessory molecules in recognition of antigen plus isolated IA.

1986 • 50 citations

Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.

1986 • 49 citations

An IL 2-secreting T cell hybridoma that responds to a self class I histocompatibility antigen in the H-2D region.

1983 • 45 citations

Distinct roles for L3T4 in T cell activation.

1987 • 3 citations