Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Transient expression of interleukin 2 receptors. Consequences for T cell growth.

1983 • 613 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Distinctive functional characteristics of human „T”︁ lymphocytes defined by E rosetting or a monoclonal anti‐T cell antibody

1981 • 498 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

1987 • 453 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells

1983 • 333 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

1981 • 306 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

1987 • 259 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Widespread occurrence of "87 kDa," a major specific substrate for protein kinase C.

1986 • 176 citations

A common pathway for T lymphocyte activation involving both the CD3-Ti complex and CD2 sheep erythrocyte receptor determinants.

1986 • 163 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

T cell activation via CD2 [T, gp50] molecules: accessory cells are required to trigger T cell activation via CD2-D66 plus CD2-9.6/T11(1) epitopes.

1985 • 150 citations

The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

1987 • 148 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphates

1987 • 137 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen.

1982 • 123 citations

T cell activation via CD2 [T, gp50]: the role of accessory cells in activating resting T cells via CD2.

1986 • 105 citations

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.

1986 • 94 citations

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

1987 • 92 citations

Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes

1987 • 91 citations

Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.

1985 • 75 citations

The role of T3 in the activation of human T cells

1984 • 62 citations

Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells

1985 • 56 citations

The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.

1987 • 48 citations

Activation-dependent phosphorylation of endogeneous protein kinase c substrates in quiescent human T lymphocytes

1988 • 21 citations

Interleukin-2 versus phorbol-ester-induced cellular events in normal T-lymphocytes

1986 • 6 citations