The mismatch repair system is required for S-phase checkpoint activation

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

2001 • 1,051 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

Rapid Destruction of Human Cdc25A in Response to DNA Damage

2000 • 768 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

2000 • 484 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Cdc25A is a novel phosphatase functioning early in the cell cycle.

1994 • 442 citations

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

2002 • 383 citations

MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae

1999 • 230 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.

1997 • 193 citations

Human MRE11 is inactivated in mismatch repair‐deficient cancers

2002 • 189 citations

Apoptosis induced by overexpression of hMSH2 or hMLH1.

1999 • 178 citations

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

1997 • 164 citations

The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation

2001 • 146 citations

Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.

1997 • 129 citations

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

1981 • 117 citations

Role of DNA mismatch repair in the cytotoxicity of ionizing radiation.

1997 • 88 citations

Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.

2001 • 74 citations

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

1999 • 66 citations

Determination of 8-Oxoguanine in Individual Cell Nucleus of Gamma-Irradiated Mammalian Cells

2001 • 24 citations