A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

The nuclear receptor ligand-binding domain: structure and function

1998 • 829 citations

A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

1999 • 788 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Human D-type cyclin

1991 • 712 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast

1998 • 514 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors

1992 • 477 citations

Mineralocorticoid and Glucocorticoid Receptor Activities Distinguished by Nonreceptor Factors at a Composite Response Element

1993 • 461 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

1995 • 431 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

The human oestrogen receptor functions in yeast

1988 • 402 citations

The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins.

1996 • 351 citations

High-Mobility Group Chromatin Proteins 1 and 2 Functionally Interact with Steroid Hormone Receptors To Enhance Their DNA Binding In Vitro and Transcriptional Activity in Mammalian Cells

1998 • 338 citations

Isoforms of steroid receptor co-activator 1differ in their ability to potentiate transcription by the oestrogen receptor

1998 • 321 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

1999 • 291 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

A Nucleoside Transporter from Trypanosoma brucei Involved in Drug Resistance

1999 • 262 citations

Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery

1997 • 260 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

The DNA-Bending Protein HMG-1 Enhances Progesterone Receptor Binding to Its Target DNA Sequences

1994 • 200 citations

Phagocytic killing of Candida albicans by different murine effector cells.

1983 • 180 citations

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins

1991 • 170 citations

LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.

1995 • 161 citations

A CTD function linking transcription to splicing

1997 • 160 citations

Yeast RSP5 and Its Human Homolog hRPF1 Potentiate Hormone-Dependent Activation of Transcription by Human Progesterone and Glucocorticoid Receptors

1996 • 160 citations

An FK506-sensitive Transporter Selectively Decreases Intracellular Levels and Potency of Steroid Hormones

1996 • 125 citations

Role for Hsp90-Associated Cochaperone p23 in Estrogen Receptor Signal Transduction

1999 • 122 citations

Essential role of Swp73p in the function of yeast Swi/Snf complex.

1996 • 119 citations

Three Amino Acid Substitutions Selectively Disrupt the Activation but Not the Repression Function of the Glucocorticoid Receptor N Terminus

1997 • 116 citations

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

1990 • 110 citations

Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.

1993 • 109 citations

Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2

1998 • 109 citations

TLS (Translocated-in-Liposarcoma) Is a High-Affinity Interactor for Steroid, Thyroid Hormone, and Retinoid Receptors

1998 • 108 citations

Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.

1993 • 105 citations

Role of the β3-Adrenergic Receptor and/or a Putative β4-Adrenergic Receptor on the Expression of Uncoupling Proteins and Peroxisome Proliferator-Activated Receptor-γ Coactivator-1

1999 • 99 citations

Identification of a negative regulatory function for steroid receptors.

1992 • 98 citations

Nerve Growth Factor Up-regulates the Transcriptional Activity of CBP through Activation of the p42/p44MAPK Cascade

1998 • 97 citations

HMG-1 Stimulates Estrogen Response Element Binding by Estrogen Receptor from Stably Transfected HeLa Cells

1999 • 91 citations

The coupling of multiple signal transduction pathways with steroid response mechanisms.

1994 • 90 citations

An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors

1999 • 90 citations

A novel cyclin gene from Drosophila complements CLN function in yeast.

1991 • 58 citations

Thyroid Hormone Export Regulates Cellular Hormone Content and Response

1996 • 48 citations

Determinants of promoter-specific activity by glucocorticoid receptor.

1996 • 48 citations

Estradiol-Inducible Squelching and Cell Growth Arrest by a Chimeric VP16-Estrogen Receptor Expressed in Saccharomyces cerevisiae: Suppression by an allele of PDR1

1993 • 46 citations

DA-Complex Assembly Activity Required for VP16C Transcriptional Activation

1998 • 40 citations