Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil

Cloned Glutamate Receptors

1994 • 3,989 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1997 • 465 citations

The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray

1993 • 435 citations

NMDA-receptor regulation of substance P release from primary afferent nociceptors

1997 • 427 citations

Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

1994 • 356 citations

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

1999 • 333 citations

A cure for wind up: NMDA receptor antagonists as potential analgesics

1990 • 327 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup

1990 • 270 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.

1997 • 192 citations

Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor

1996 • 159 citations

Antinociceptive activity of CP‐101,606, an NMDA receptor NR2B subunit antagonist

1997 • 128 citations

Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat

1991 • 126 citations

CP-101,606, a potent neuroprotectant selective for forebrain neurons

1997 • 109 citations

The role of N‐methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.

1987 • 104 citations

Pharmacological properties of recombinant N-methyl-d-aspartate (NMDA) receptors containing the ϵ4 (NR2D) subunit

1995 • 100 citations

Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells

1996 • 100 citations

An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.

1996 • 83 citations

Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-d-aspartate receptors?

1988 • 78 citations

Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine, in mice

1996 • 55 citations

The Neuroprotective Effect of the Forebrain-S elective NMD A Antagonist CP101,606 upon Focal Ischemic Brain Damage Caused by Acute Subdural Hematoma in the Rat

1997 • 39 citations

Stimulus intensity, cell excitation and the N-methyl-d-aspartate receptor component of sensory responses in the rat spinal cord in vivo

1997 • 36 citations

Thyrotropin-releasing hormone (TRH)-induced facilitation of spinal neurotransmission: A role for NMDA receptors

1994 • 21 citations

Effects of NMDA receptor antagonists on nociceptive responsesin vivo: Comparison of antagonists acting at the glycine site with uncompetitive antagonists

1998 • 4 citations