Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Determination of protein: A modification of the lowry method that gives a linear photometric response

1972 • 5,490 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine

1989 • 408 citations

The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

1994 • 320 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

Presence of Kynurenic Acid in the Mammalian Brain

1988 • 273 citations

Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes

1988 • 258 citations

Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

1990 • 199 citations

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

1990 • 198 citations

Glutamate antagonists have different effects on spontaneous locomotor activity in rats

1994 • 186 citations

Excitotoxic index — a biochemical marker of selective vulnerability

1991 • 178 citations

Glycine modulates [3H]MK-801 binding to the NMDA receptor in rat brain

1987 • 160 citations

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.

1993 • 156 citations

Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

1992 • 140 citations

In vivo Models of Cerebral Ischemia: Effects of Parenterally Administered NMDA Receptor Glycine Site Antagonists

1995 • 117 citations

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

1990 • 117 citations

Quinoxaline derivatives are high-affinity antagonists of the NMDA receptor-associated glycine sites

1989 • 105 citations

Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning

1990 • 101 citations

NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin

1993 • 98 citations

N-Methyl-d-aspartic acid-induced lethality in mice: selective antagonism by phencylidine-like drugs

1988 • 97 citations

Lack of effect of L‐687,414 ((+)‐cis‐4‐methyl‐HA‐966)₅ an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology

1993 • 89 citations

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex

1993 • 87 citations

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

1993 • 84 citations

Inhibition of cortical spreading depression by L‐701,324, a novel antagonist at the glycine site of the N‐methyl‐D‐aspartate receptor complex

1996 • 71 citations

Anticonvulsant effects of the glycine/NMDA receptor ligands <scp>d</scp>‐cycloserine and <scp>d</scp>‐serine but not R‐(+)‐HA‐966 in amygdala‐kindled rats

1994 • 67 citations

[3H]5,7-Dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites

1991 • 66 citations

Chemically-diverse ligands at the glycine B site coupled to (NMDA) receptors selectively block the late phase of formalin-induced pain in mice

1994 • 62 citations

The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.

1996 • 62 citations

Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord

1995 • 59 citations

Systemic dl-Kynurenine and probenecid pretreatment attenuates quinolinic acid-induced neurotoxicity in rats

1996 • 57 citations

Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methylendioxyl-5H-2,3-benzodiazepine (GYKI 52466)

1994 • 57 citations

The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat

1995 • 55 citations

A study of the dose dependency of a glycine receptor antagonist in focal ischemia.

1993 • 54 citations

Support for Radiolabeling of a Glycine Recognition Domain on the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Ionophore Complex by 5,7‐[³H]Dichlorokynurenate in Rat Brain

1993 • 51 citations

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

1997 • 47 citations

Common and uncommon behavioural effects of antagonists for different modulatory sites in the NMDA receptor/channel complex

1993 • 45 citations

The glycine antagonist and free radical scavenger 7-C1-thio-kynurenate reduces CA1 ischemic damage in the gerbil

1994 • 42 citations

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

1996 • 41 citations

The Effect of the Glycine Site-Specific N-Methyl-<scp>d</scp>-Aspartate Antagonist ACEA1021 on Ischemic Brain Damage Caused by Acute Subdural Hematoma in the Rat

1995 • 41 citations

Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

1994 • 41 citations

A physiologist's view of the N‐methyl‐D‐Aspartate receptor: An allosteric ion channel with multiple regulatory sites

1989 • 40 citations

Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.

1992 • 39 citations

Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists

1995 • 39 citations

The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam

1994 • 39 citations

Whole cell and single channel analysis of the kinetics of glycine‐sensitive N‐methyl‐D‐aspartate receptor desensitization

1993 • 39 citations

MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles

1995 • 35 citations

Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.

1991 • 35 citations

Thiokynurenates prevent excitotoxic neuronal death in vitro and in vivo by acting as glycine antagonists and as inhibitors of lipid peroxidation

1992 • 33 citations

Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures

1995 • 33 citations

Review Central &amp; Peripheral Nervous Systems: Glycine-site NMDA receptor antagonists

1995 • 29 citations

Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

1994 • 29 citations

Differential effects of compounds that act at strychnine-insensitive glycine receptors in a punishment procedure.

1994 • 28 citations

Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist.

1995 • 23 citations

EEG seizure activity and behavioral neurotoxicity produced by (+)-MK801, but not the glycine site antagonist L-687,414, in the rat

1996 • 22 citations

Characterisation of the binding of [3H]MDL 105,519, a radiolabelled antagonist for the N-methyl-d-aspartate-associated glycine site, to pig cortical brain membranes

1997 • 19 citations

Feibamate, a novel antiepileptic agent, does not affect cognition in rodents

1994 • 11 citations

Differential effects of five glycine site antagonists on NMDA receptor desensitisation

1996 • 10 citations

NMDA receptors mediate spontaneous activity, but not phasic synaptic responses in the spinal dorsal horn of the anaesthetized rat

1996 • 1 citations