Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity.

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Lectins as Cell Recognition Molecules

1989 • 1,204 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus.

1985 • 445 citations

Expression of a transposable antibiotic resistance element in Saccharomyces

1980 • 428 citations

Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.

1985 • 413 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 385 citations

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

1995 • 380 citations

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 330 citations

Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.

1992 • 308 citations

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

1995 • 235 citations

A Vector That Replicates as a Plasmid and Can Be Efficiently Selected in B-Lymphoblasts Transformed by Epstein-Barr Virus

1985 • 187 citations

Participation of endothelial cells in the protein C-protein S anticoagulant pathway: the synthesis and release of protein S.

1986 • 157 citations

Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells.

1988 • 154 citations

Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages

1991 • 122 citations

Functionally Active Thrombomodulin Is Present in Human Platelets1

1988 • 107 citations

Detecting distant homologies of mosaic proteins

1988 • 93 citations

Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays

1990 • 86 citations

The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.

1988 • 84 citations

A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets

1993 • 80 citations

Regional distribution of thrombomodulin in human brain

1991 • 79 citations

Distribution of the thrombomodulin antigen in the rabbit vasculature.

1986 • 78 citations

Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation.

1994 • 72 citations

Preservation of thrombomodulin antigen on vascular and extravascular surfaces.

1987 • 70 citations

Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

1992 • 69 citations

Fetomodulin: Marker surface protein of fetal development which is modulatable by cyclic AMP

1987 • 64 citations

Expression of thrombomodulin in esophageal squamous cell carcinoma and its relationship to lymph node metastasis.

1995 • 64 citations

Expression of thrombomodulin by smooth muscle cells in culture: different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture

1991 • 64 citations

Thrombomodulin inhibits intrahepatic spread in human hepatocellular carcinoma

1995 • 58 citations

Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos

1996 • 57 citations

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

1993 • 57 citations

Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells.

1992 • 52 citations

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay.

1988 • 50 citations

The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells

1995 • 49 citations

Epstein-Barr Virus Shuttle Vector for Stable Episomal Replication of cDNA Expression Libraries in Human Cells

1988 • 45 citations

Expression of thrombomodulin in astrocytomas of various malignancy and in gliotic and normal brains

1994 • 37 citations

Cellular localization of thrombomodulin in human epithelium and squamous malignancies.

1995 • 36 citations

Detection of thrombomodulin in human lung cancer cells.

1993 • 35 citations

Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours

1995 • 32 citations

Localization and Biosynthesis of Functional Thrombomodulin in Human Megakaryocytes and a Human Megakaryoblastic Cell Line (MEG-01)

1990 • 29 citations

Thrombomodulin lacking the cytoplasmic domain efficiently internalizes thrombin via nonclathrin‐coated, pit‐mediated endocytosis

1994 • 23 citations

A thrombin-based peptide corresponding to the sequence of the thrombomodulin-binding site blocks the procoagulant activities of thrombin.

1991 • 20 citations

Differential expression of fetomodulin and tissue plasminogen activator to characterize parietal endoderm differentiation of F9 embryonal carcinoma cells

1990 • 18 citations

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay.

1988 • 12 citations

cAMP influence on transcription of thrombomodulin is dependent on de novo synthesis of a protein intermediate: evidence for cohesive regulation of myogenic proteins in vascular smooth muscle.

1995 • 8 citations