Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin.

1981 • 811 citations

Fluorimetry Study of N‐(1‐Pyrenyl)iodoacetamide‐Labelled F‐Actin

1981 • 694 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides.

1990 • 304 citations

Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin.

1987 • 256 citations

gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein

1990 • 225 citations

Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin.

1992 • 206 citations

Identification of a region in segment 1 of gelsolin critical for actin binding.

1990 • 205 citations

Gelsolin-Polyphosphoinositide Interaction

1989 • 200 citations

Expression of human plasma gelsolin in Escherichia coli and dissection of actin binding sites by segmental deletion mutagenesis.

1989 • 195 citations

Identification of critical functional and regulatory domains in gelsolin.

1989 • 194 citations

The actin filament-severing domain of plasma gelsolin.

1986 • 174 citations

Gelsolin has three actin-binding sites.

1988 • 156 citations

Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.

1989 • 151 citations

Identification of a polyphosphoinositide-modulated domain in gelsolin which binds to the sides of actin filaments.

1988 • 148 citations

Functional comparison of villin and gelsolin. Effects of Ca2+, KCl, and polyphosphoinositides.

1988 • 145 citations

Villin sequence and peptide map identify six homologous domains.

1988 • 136 citations

The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.

1990 • 117 citations

Pieces in the actin-severing protein puzzle

1988 • 112 citations

Isolation and properties of two actin-binding domains in gelsolin.

1985 • 105 citations

Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids

1991 • 104 citations

Cloning and characterization of porcine brain cofilin cDNA. Cofilin contains the nuclear transport signal sequence.

1988 • 103 citations

Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.

1989 • 94 citations

Two of the three actin‐binding domains of gelsolin bind to the same subdomain of actin Implications for capping and severing mechanisms

1991 • 73 citations

Severin is a gelsolin prototype

1990 • 55 citations

Inhibition of actin regulatory activity of the 74-kDa protein from bovine adrenal medulla (adseverin) by some phospholipids.

1990 • 54 citations

Are the conserved sequences in segment 1 of gelsolin important for binding actin?

1992 • 45 citations

Chimeric and truncated gCap39 elucidate the requirements for actin filament severing and end capping by the gelsolin family of proteins.

1991 • 41 citations

The primary structure of human platelet profilin: Reinvestigation of the calf spleen profilin sequence

1988 • 39 citations

The interaction of monomeric actin with two binding sites on Acanthamoeba actobindin

1991 • 39 citations