Interaction of Scorpion α-Toxins with Cardiac Sodium Channels

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 • 624 citations

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

1996 • 410 citations

Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance.

1978 • 263 citations

Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

1997 • 221 citations

Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

1998 • 193 citations

Impaired slow inactivation in mutant sodium channels

1996 • 179 citations

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca ²⁺ and K ⁺ channels

1998 • 165 citations

A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action

1990 • 165 citations

α-Helical Structural Elements within the Voltage-Sensing Domains of a K+ Channel

1999 • 163 citations

Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topology.

1989 • 152 citations

Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis

1997 • 136 citations

Interaction between fast and slow inactivation in Skm1 sodium channels

1996 • 133 citations

External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.

1996 • 132 citations

Identification of Structural Elements of a Scorpion α-Neurotoxin Important for Receptor Site Recognition

1997 • 120 citations

Localization and Molecular Determinants of the Hanatoxin Receptors on the Voltage-Sensing Domains of a K+ Channel

2000 • 120 citations

A mutation in segment I-S6 alters slow inactivation of sodium channels

1997 • 114 citations

A Specific Interaction between the Cardiac Sodium Channel and Site-3 Toxin Anthopleurin B

1998 • 109 citations

A Structural Rearrangement in the Sodium Channel Pore Linked to Slow Inactivation and Use Dependence

2000 • 105 citations

Slow Inactivation in Human Cardiac Sodium Channels

1998 • 100 citations

A Hot Spot for the Interaction of Gating Modifier Toxins with Voltage-Dependent Ion Channels

2000 • 96 citations

Structural Determinants of Slow Inactivation in Human Cardiac and Skeletal Muscle Sodium Channels

1999 • 79 citations

Role of Domain 4 in Sodium Channel Slow Inactivation

2000 • 76 citations

Voltage-Dependent Inhibition of N- and P-Type Calcium Channels by the Peptide Toxin ω-Grammotoxin-SIA

1997 • 75 citations

Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and LqhαIT

2000 • 75 citations

Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-gated Na+ Channels

1998 • 74 citations

NMR structures and activity of a novel α-like toxin from the scorpion Leiurus quinquestriatus hebraeus 1 1Edited by J. Thornton

1999 • 72 citations

New toxins acting on sodium channels from the scorpion Leiurus quinquestriatus hebraeus suggest a clue to mammalian vs insect selectivity

1998 • 72 citations

Sea Anemone Toxin (ATX II) Modulation of Heart and Skeletal Muscle Sodium Channel α-Subunits Expressed in tsA201 Cells

1996 • 50 citations

Augmentation of Recovery from Inactivation by Site-3 Na Channel Toxins

1999 • 45 citations

Human Na+ channel fast and slow inactivation in paramyotonia congenita mutants expressed in Xenopus laevis oocytes.

1997 • 44 citations

Comparison of slow inactivation in human heart and rat skeletal muscle Na⁺ channel chimaeras

1999 • 41 citations

Differences in the binding sites of two site-3 sodium channel toxins

1997 • 39 citations

Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels

1996 • 35 citations

Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin

1994 • 34 citations

Dual actions of tetracaine on intramembrane charge in amphibian striated muscle

1997 • 17 citations