A Hot Spot for the Interaction of Gating Modifier Toxins with Voltage-Dependent Ion Channels

Ionic channels of excitable membranes

1985 • 7,199 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

From Ionic Currents to Molecular Mechanisms

2000 • 2,039 citations

Ionic Channels of Excitable Membranes, 2nd Ed.

1992 • 1,283 citations

The Ionic Channels in Excitable Membranes

1975 • 1,096 citations

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

1992 • 877 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels

1999 • 425 citations

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

1996 • 410 citations

Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

1998 • 401 citations

Voltage-Gated Ion Channels and Electrical Excitability

1998 • 373 citations

The charybdotoxin family of K+ channel-blocking peptides

1995 • 341 citations

Voltage Sensor–Trapping

1998 • 328 citations

Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites

1997 • 239 citations

Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

1997 • 221 citations

Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel

1991 • 219 citations

Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels.

1991 • 218 citations

Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin

1998 • 199 citations

Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

1975 • 194 citations

Cloning and tissue‐specific expression of the brain calcium channel β‐subunit

1991 • 186 citations

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca ²⁺ and K ⁺ channels

1998 • 165 citations

α-Helical Structural Elements within the Voltage-Sensing Domains of a K+ Channel

1999 • 163 citations

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation.

1979 • 158 citations

The Na Channel Voltage Sensor Associated with Inactivation Is Localized to the External Charged Residues of Domain IV, S4

1999 • 152 citations

Gating of Na channels. Inactivation modifiers discriminate among models.

1987 • 150 citations

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins

2000 • 145 citations

Helical Structure and Packing Orientation of the S2 Segment in the Shaker K+ Channel

1999 • 132 citations

A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain.

1994 • 122 citations

Localization and Molecular Determinants of the Hanatoxin Receptors on the Voltage-Sensing Domains of a K+ Channel

2000 • 120 citations

The Lipid–Protein Interface of aShaker K+ Channel

1999 • 112 citations

Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses.

1993 • 109 citations

.delta.-Conotoxin GmVIA, a Novel Peptide from the Venom of Conus gloriamaris

1994 • 84 citations

Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA

1997 • 83 citations

Molecular properties of sodium and calcium channels

1996 • 81 citations

Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.

1995 • 80 citations

Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus.

1983 • 78 citations

Three‐dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution determined by nuclear magnetic resonance spectroscopy

1989 • 78 citations

Voltage-Dependent Inhibition of N- and P-Type Calcium Channels by the Peptide Toxin ω-Grammotoxin-SIA

1997 • 75 citations

Structural Elements in Domain IV that Influence Biophysical and Pharmacological Properties of Human α1A-Containing High-Voltage-Activated Calcium Channels

1999 • 74 citations

Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves.

1986 • 73 citations

Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.

1995 • 71 citations

Interactions of Scorpion Toxins with the Sodium Channel

1986 • 69 citations

Three-dimensional Solution Structure of the Calcium Channel Antagonist ω-Agatoxin IVA: Consensus Molecular Folding of Calcium Channel Blockers

1995 • 68 citations

A New Conotoxin Affecting Sodium Current Inactivation Interacts with the δ-Conotoxin Receptor Site

1995 • 58 citations

Sequential assignment and structure determination of spider toxin .omega.-Aga-IVB

1993 • 58 citations

Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A

1995 • 55 citations

The solution structure of ?-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta

1995 • 44 citations

Solution structure of an Old World-like neurotoxin from the venom of the New World scorpion Centruroides sculpturatus Ewing

1995 • 37 citations

Effects of Leiurus scorpion venom on the "gating" current in myelinated nerve.

1979 • 34 citations

Gating current experiments on frog nodes of Ranvier treated withCentruroides sculpturatus toxins or aconitine

1987 • 10 citations