Heterogeneity in P‐glycoprotein (multidrug resistance) activity among murine peripheral T cells: Correlation with surface phenotype and effector function

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens

1984 • 655 citations

Physiological and Molecular Mechanisms of Lymphocyte Homing

1992 • 655 citations

Lifespan of human lymphocyte subsets defined by CD45 isoforms

1992 • 642 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Aging and Immune Function

1991 • 361 citations

P-glycoprotein expression and function in circulating blood cells from normal volunteers

1994 • 350 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype [see comments]

1992 • 323 citations

Immunological Memory

1993 • 250 citations

Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells.

1990 • 236 citations

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A

1991 • 218 citations

Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.

1989 • 185 citations

Memory B and T Cells

1991 • 183 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.

1991 • 179 citations

Immunological Memory

1993 • 166 citations

Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor.

1992 • 165 citations

The Cellular Basis of T-Cell Memory

1989 • 161 citations

Production of Interferon-Gamma during Infection of Mice with Plasmodium chabaudi chabaudi

1989 • 157 citations

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

1990 • 141 citations

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

1991 • 126 citations

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

1987 • 120 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection

1989 • 101 citations

Multidrug resistance activity in human lymphocytes

1991 • 100 citations

Increased function of P-glycoprotein in T lymphocyte subsets of aging mice.

1993 • 99 citations

Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.

1992 • 65 citations

Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4.

1989 • 56 citations

Bacterial superantigens induce rapid and T cell receptor V beta-selective down-regulation of L-selectin (gp90Mel-14) in vivo.

1993 • 47 citations

BALB.D2-Mlsa-A new congenic mouse strain

1984 • 47 citations

Murine CD4⁺ T‐Cell Subsets

1991 • 38 citations

CD45RB expression defines two interconvertible subsets of human CD4⁺ T cells with memory function

1994 • 20 citations

Hyper-reactivity of mouse CD45RA− T cells

1993 • 11 citations

Quantitative and qualitative differences in IL-2 and IL-4 expression in primary and secondary T cell stimulation

1992 • 3 citations