Functional intracellular P‐glycoprotein

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

1993 • 443 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

1992 • 322 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients

1993 • 168 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Hoechst 33342 dye uptake as a probe of membrane permeability changes in mammalian cells.

1981 • 152 citations

Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines

1993 • 149 citations

A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.

1993 • 148 citations

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug resistant cells expressing different levels of P-glycoprotein

1992 • 102 citations

Expression of the multidrug resistance associated protein and P- glycoprotein in doxorubicin-selected human myeloid leukemia cells

1994 • 81 citations

Absorption and circular dichroic spectral studies on the self‐association of daunorubicin

1980 • 74 citations

Using purified P-glycoprotein to understand multidrug resistance

1995 • 67 citations

Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells

1993 • 61 citations

Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage.

1992 • 55 citations

Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.

1992 • 55 citations

Sequestration of doxorubicin in vesicles in a multidrug-resistant cell line (LZ-100)

1994 • 54 citations

An Atlas of Immunofluorescence in Cultured Cells

1985 • 52 citations

Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft.

1992 • 49 citations

An atlas of immunofluorescence in cultured cells

1986 • 49 citations

Cytofluorescence localization of adriamycin in resistant colon cancer cells

1984 • 44 citations

Evidence for cytoplasmic P-glycoprotein location associated with increased multidrug resistance and resistance to chemosensitizers.

1996 • 43 citations

Low-level doxorubicin resistance in P-glycoprotein-negative human pancreatic tumour PSN1/ADR cells implicates a brefeldin A-sensitive mechanism of drug extrusion

1996 • 39 citations