Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage.

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.

1987 • 850 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

1988 • 415 citations

Mitoxantrone: A New Anticancer Drug with Significant Clinical Activity

1986 • 288 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

Experimental antitumor activity of aminoanthraquinones.

1979 • 131 citations

Interactions of antitumor agents ametantrone∗∗Trade name for the salt of 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (Fig. 1, I). Abbreviations: HAQ, ANT; NSC-287513. and mitoxantrone (novatrone)††Trade name for the salt of 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino] -9,10- anthracenedione (Fig. 1, II). Abbreviation: DHAQ; NSC-279836 and NSC-301739. with double-stranded DNA

1985 • 124 citations

Cytofluorescence localization of adriamycin and daunorubicin.

1974 • 121 citations

Lysosomal localization and mechanism of uptake of Nile blue photosensitizers in tumor cells.

1991 • 106 citations

Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids.

1986 • 104 citations

Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone.

1990 • 81 citations

Comparative molecular pharmacology in leukemic L1210 cells of the anthracene anticancer drugs mitoxantrone and bisantrene.

1985 • 73 citations

Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line.

1989 • 71 citations

High Field¹H-NMR Analysis of the 1:1 Intercalation Complex of the Antitumor Agent Mitoxantrone and the DNA Duplex [d(CpGpCpG)]₂

1985 • 68 citations

Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy.

1984 • 68 citations

Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells

1990 • 65 citations

Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A

1989 • 62 citations

Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin)

1990 • 57 citations

Evidence for human liver mediated free-radical formation by doxorubicin and mitozantrone.

1985 • 51 citations

Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs.

1988 • 47 citations

DNA sequence preferences for the anti‐cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting

1986 • 43 citations

Selective displacement of nuclear proteins by antitumor drugs having affinity for nucleic acids.

1989 • 36 citations

The in vitro effects and cross-resistance patterns of some novel anthracyclines

1986 • 33 citations

Differences in daunomycin retention in sensitive and resistant P388 leukemic cells as determined by digitized video fluorescence microscopy.

1983 • 28 citations

Persistent intracellular binding of mitoxantrone in a human colon carcinoma cell line

1989 • 23 citations

Therapy of adult acute lymphocytic leukemia.

1984 • 23 citations

Development of Resistance and Characteristics of a Human Colon Carcinoma Subline Resistant to Mitoxantrone in vitro

1987 • 20 citations

Reduced nuclear binding of a DNA minor groove ligand (Hoechst 33342) and its impact on cytotoxicity in drug resistant murine cell lines

1990 • 17 citations

Alteration of binding of the supravital dye Hoechst 33342 to human leukemic cells by adriamycin.

1978 • 16 citations

Chromatin modifications associated with N-methylformamide-induced radiosensitization of clone A cells.

1988 • 14 citations

A linear transform of the multi-target survival curve

1978 • 14 citations

Studies on the fluorescence labeling of human red blood cell membrane ghosts with 4′-(9-acridinylamino) methanesulfon-m-anisidide

1985 • 4 citations