Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes

Surfing the p53 network

2000 • 6,487 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

2000 • 994 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

The MDM2 gene amplification database

1998 • 958 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

MDM2 — master regulator of the p53 tumor suppressor protein

2000 • 637 citations

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

1997 • 565 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

1999 • 453 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Promoter targeting and chromatin remodeling by the SWI/SNF complex

2000 • 433 citations

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

2000 • 415 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit

2001 • 369 citations

Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo

2001 • 369 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

FAT: a novel domain in PIK-related kinases

2000 • 300 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation

2001 • 205 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

Transcription Activator Interactions with Multiple SWI/SNF Subunits

2002 • 183 citations

Identification of TATA-binding Protein-free TAFII-containing Complex Subunits Suggests a Role in Nucleosome Acetylation and Signal Transduction

1999 • 181 citations

A Human SPT3-TAFII31-GCN5-L Acetylase Complex Distinct from Transcription Factor IID

1998 • 179 citations

The p53 gene family

1999 • 174 citations

The 400 kDa Subunit of the PCAF Histone Acetylase Complex Belongs to the ATM Superfamily

1998 • 160 citations

Myc represses the growth arrest gene gadd45

1997 • 149 citations

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

2001 • 139 citations

Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes

1998 • 137 citations

The α-helical FXXΦΦ motif in p53: TAF interaction and discrimination by MDM2

1999 • 132 citations

Promoter targeting of chromatin-modifying complexes

2001 • 129 citations

E2F Transcriptional Activation Requires TRRAP and GCN5 Cofactors

2001 • 128 citations

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

1999 • 127 citations

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

1995 • 126 citations

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

2000 • 123 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

1996 • 112 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

Adenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF

2000 • 98 citations

hADA3 is required for p53 activity

2001 • 96 citations

Cdk2-dependent and -independent Pathways in E2F-mediated S Phase Induction

2000 • 91 citations

The PCAF acetylase complex as a potential tumor suppressor

2000 • 90 citations

Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells.

1990 • 68 citations

Voltage-Insensitive Ca²⁺ Channels and Ca²⁺/Calmodulin-Dependent Protein Kinases Propagate Signals from Endothelin-1 Receptors to the c-fos Promoter

1996 • 59 citations

Stabilization and Activation of p53 by the Coactivator Protein TAFII31

2001 • 41 citations

p53 binds to a constitutively nucleosome free region of the mdm2 gene

1998 • 29 citations

FRAP DNA-Dependent Protein Kinase Mediates a Late Signal Transduced from Ultraviolet-Induced DNA Damage

2000 • 28 citations