Epigenotype switching of imprintable loci in embryonic germ cells

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture

1992 • 1,205 citations

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

1991 • 904 citations

Long-term proliferation of mouse primordial germ cells in culture

1992 • 873 citations

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

1993 • 807 citations

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

1992 • 729 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells

1997 • 469 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines

1994 • 354 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse

1995 • 288 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization

1995 • 274 citations

Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting.

1995 • 263 citations

Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein

1996 • 252 citations

Stem Cells from Primordial Germ Cells Can Reenter the Germ Line

1994 • 250 citations

Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse

1996 • 246 citations

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis

1991 • 246 citations

Genomic imprinting and the differential roles of parental genomes in brain development

1996 • 210 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

Androgenetic mouse embryonic stem cells are pluripotent and cause skeletal defects in chimeras: Implications for genetic imprinting

1990 • 147 citations

Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cell lines

1994 • 145 citations

Assignment of genes to regions of mouse chromosomes.

1978 • 144 citations

Influence of paternally imprinted genes on development

1991 • 108 citations

Temporal and spatial selection against parthenogenetic cells during development of fetal chimeras

1990 • 105 citations

Genetic and Functional Analysis of neuronatin in Mice with Maternal or Paternal Duplication of Distal Chr 2

1997 • 98 citations

Methylation of CpG sites of two X–linked genes coincides with X–inactivation in the female mouse embryo but not in the germ line

1992 • 90 citations

Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1

1997 • 85 citations

Parental methylation patterns of a transgenic locus in adult somatic tissues are imprinted during gametogenesis

1992 • 57 citations

Developmental Regulation of Genomic Imprinting during Gametogenesis

1995 • 45 citations

Immortal germ cells?

1993 • 29 citations