The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

1986 • 688 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2A_c

1995 • 582 citations

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

1995 • 440 citations

Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

1989 • 437 citations

Role of the AMP-activated protein kinase in the cellular stress response

1994 • 430 citations

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

1994 • 330 citations

Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I

1995 • 322 citations

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

1994 • 251 citations

Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA.

1991 • 211 citations

Purification of the AMP‐activated protein kinase on ATP‐γ‐Sepharose and analysis of its subunit structure

1994 • 161 citations

A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.

1994 • 143 citations

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.

1994 • 123 citations

An antibody VH domain with a lox -Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain

1995 • 116 citations

Biochemical evidence for the existence of gamma-aminobutyrateA receptor iso-oligomers.

1990 • 100 citations

Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress

1994 • 89 citations

Synergy in Protein Engineering

1996 • 33 citations