Hydrophobic mismatch between proteins and lipids in membranes

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

1996 • 1,581 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Mattress model of lipid-protein interactions in membranes

1984 • 734 citations

Cubic phases and isotropic structures formed by membrane lipids — possible biological relevance

1989 • 525 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

The Lateral Pressure Profile in Membranes: A Physical Mechanism of General Anesthesia

1997 • 453 citations

Signal sequences

1989 • 417 citations

Modulation of rhodopsin function by properties of the membrane bilayer

1994 • 413 citations

An investigation of the role of transmembrane domains in Golgi protein retention.

1995 • 384 citations

Non-random Distribution of Amino Acids in the Transmembrane Segments of Human Type I Single Span Membrane Proteins

1993 • 378 citations

Wild-type Escherichia coli Cells Regulate the Membrane Lipid Composition in a “Window” between Gel and Non-lamellar Structures

1996 • 365 citations

Lipid polymorphism and protein–lipid interactions

1998 • 351 citations

The function of tryptophan residues in membrane proteins

1992 • 344 citations

Combined influence of cholesterol and synthetic amphiphillic peptides upon bilayer thickness in model membranes

1992 • 309 citations

Induction of Nonbilayer Structures in Diacylphosphatidylcholine Model Membranes by Transmembrane α-Helical Peptides: Importance of Hydrophobic Mismatch and Proposed Role of Tryptophans

1996 • 266 citations

Neutron scattering in the plane of membranes: structure of alamethicin pores

1996 • 234 citations

Fluorescence quenching of model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics

1981 • 232 citations

Influence of Lipid/Peptide Hydrophobic Mismatch on the Thickness of Diacylphosphatidylcholine Bilayers. A ²H NMR and ESR Study Using Designed Transmembrane α-Helical Peptides and Gramicidin A

1998 • 231 citations

Signal peptides: exquisitely designed transport promoters

1994 • 231 citations

A molecular model for lipid-protein interaction in membranes: the role of hydrophobic mismatch

1993 • 219 citations

Gramicidin and gramicidin-lipid interactions

1992 • 218 citations

Engineering the Gramicidin Channel

1996 • 215 citations

Mechanism of alamethicin insertion into lipid bilayers

1996 • 213 citations

Theoretical analysis of protein organization in lipid membranes

1998 • 211 citations

MOLECULAR GENETICS OF MEMBRANE PHOSPHOLIPID SYNTHESIS

1986 • 206 citations

X-ray diffraction study of lipid bilayer membranes interacting with amphiphilic helical peptides: diphytanoyl phosphatidylcholine with alamethicin at low concentrations

1995 • 198 citations

Lipids beyond the bilayer

1997 • 195 citations

The effect of bilayer thickness and n-alkanes on the activity of the (Ca2+ + Mg2+)-dependent ATPase of sarcoplasmic reticulum.

1981 • 182 citations

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

1992 • 180 citations

Lipid polymorphism and biomembrane function

1997 • 171 citations

Transmembrane Orientation of Hydrophobic α-Helices Is Regulated Both by the Relationship of Helix Length to Bilayer Thickness and by the Cholesterol Concentration

1997 • 163 citations

The effect of bilayer thickness on the activity of (Na+ + K+)-ATPase

1981 • 159 citations

Calorimetric and spectroscopic studies of the polymorphic phase behavior of a homologous series of n-saturated 1,2-diacyl phosphatidylethanolamines

1993 • 147 citations

The membrane as an environment of minimal interconversion. A circular dichroism study on the solvent dependence of the conformational behavior of gramicidin in diacylphosphatidylcholine model membranes

1988 • 147 citations

The COOH-terminal ends of internal signal and signal-anchor sequences are positioned differently in the ER translocase.

1994 • 146 citations

Multiple Determinants Direct the Orientation of Signal–Anchor Proteins: The Topogenic Role of the Hydrophobic Signal Domain

1997 • 145 citations

Non-bilayer lipids are required for efficient protein transport across the plasma membrane of Escherichia coli.

1995 • 144 citations

Interaction of a peptide model of a hydrophobic transmembrane .alpha.-helical segment of a membrane protein with phosphatidylcholine bilayers: Differential scanning calorimetric and FTIR spectroscopic studies

1992 • 138 citations

Mutational analysis of the Golgi retention signal of bovine beta-1,4-galactosyltransferase

1993 • 137 citations

Bacteriorhodopsin remains dispersed in fluid phospholipid bilayers over a wide range of bilayer thicknesses

1983 • 137 citations

How lipids interact with an intrinsic membrane protein: the case of the calcium pump

1998 • 136 citations

Nonlamellar Phases Induced by the Interaction of Gramicidin S with Lipid Bilayers. A Possible Relationship to Membrane-Disrupting Activity

1997 • 130 citations

The conformational preference of gramicidin channels is a function of lipid bilayer thickness¹

1997 • 123 citations

The Transmembrane Domain of a Carboxyl-terminal Anchored Protein Determines Localization to the Endoplasmic Reticulum

1997 • 122 citations

Transmembrane helix structure, dynamics, and interactions: multi-nanosecond molecular dynamics simulations

1997 • 117 citations

Lipid domains and lipid/protein interactions in biological membranes

1994 • 117 citations

Refined Structure of the Porin from Rhodopseudomonas blastica

1994 • 116 citations

A Three-Dimensional Difference Map of the N Intermediate in the Bacteriorhodopsin Photocycle: Part of the F Helix Tilts in the M to N Transition

1996 • 114 citations

Protein rotational diffusion and lipid/protein interactions in recombinants of bovine rhodopsin with saturated diacylphosphatidylcholines of different chain lengths studied by conventional and saturation-transfer electron spin resonance

1992 • 113 citations

Systematic analysis of stop-transfer sequence for microsomal membrane

1991 • 112 citations

Polymorphic regulation of membrane lipid composition

1987 • 110 citations

Effect of changing the size of lipid headgroup on peptide insertion into membranes

1997 • 110 citations

Hydrophobic Mismatch and the Incorporation of Peptides into Lipid Bilayers: A Possible Mechanism for Retention in the Golgi

1998 • 109 citations

Molecular sorting of lipids by bacteriorhodopsin in dilauroylphosphatidylcholine/distearoylphosphatidylcholine lipid bilayers

1997 • 109 citations

Induction of non-bilayer lipid structures by functional signal peptides.

1990 • 107 citations

Monte Carlo simulation studies of lipid order parameter profiles near integral membrane proteins

1991 • 107 citations

Peptide Models of Helical Hydrophobic Transmembrane Segments of Membrane Proteins. 1. Studies of the Conformation, Intrabilayer Orientation, and Amide Hydrogen Exchangeability of Ac-K2-(LA)12-K2-Amide

1995 • 97 citations

A mutant cytochrome b5 with a lengthened membrane anchor escapes from the endoplasmic reticulum and reaches the plasma membrane.

1996 • 95 citations

Spin-label saturation-transfer electron spin resonance detection of transient association of rhodopsin in reconstituted membranes

1982 • 94 citations

Peptide Models of Helical Hydrophobic Transmembrane Segments of Membrane Proteins. 2. Differential Scanning Calorimetric and FTIR Spectroscopic Studies of the Interaction of Ac-K2-(LA)12-K2-amide with Phosphatidylcholine Bilayers

1995 • 92 citations

Effects of Membrane Thickness on the Molecular Dynamics and Enzymic Activity of Reconstituted Ca-ATPase

1994 • 87 citations

Cytochrome c oxidase

1996 • 86 citations

Small concentrations of alamethicin induce a cubic phase in bulk phosphatidylethanolamine mixtures

1996 • 85 citations

Lipid compositional manipulation in Acholeplasma laidlawii B. Effect of exogenous fatty acids on fatty acid composition and cell growth when endogenous fatty acid production is inhibited

1978 • 82 citations

Dependence of lipid membrane phase transition temperature on the mismatch of protein and lipid hydrophobic thickness

1988 • 81 citations

The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli

1997 • 78 citations

The Lactose Permease Meets Frankenstein

1994 • 76 citations

Bilayer thickness and enzymatic activity in the mitochondrial cytochrome c oxidase and ATPase complex

1982 • 74 citations

Artificial Transmembrane Segments.

1995 • 73 citations

Structure and dynamics of an amphiphilic peptide in a lipid bilayer: a molecular dynamics study

1997 • 69 citations

Hydrophobic mismatch and long‐range protein/lipid interactions in bacteriorhodopsin/phosphatidylcholine vesicles

1993 • 69 citations

Hydrophobic membrane thickness and lipid-protein interactions of the leucine transport system of Lactococcus lactis

1991 • 66 citations

Thermodynamic, motional, and structural aspects of the gramicidin-induced hexagonal HII phase formation in phosphatidylethanolamine

1985 • 65 citations

Gramicidin A/Short-Chain Phospholipid Dispersions: Chain Length Dependence of Gramicidin Conformation and Lipid Organization

1994 • 65 citations

Evidence for phospholipid microdomain formation in liquid crystalline liposomes reconstituted with Escherichia coli lactose permease

1997 • 62 citations

Elastic Interactions of Photosynthetic Reaction Center Proteins Affecting Phase Transitions and Protein Distributions

1986 • 60 citations

Structural stability of the erythrocyte anion transporter, band 3, in different lipid environments. A differential scanning calorimetric study.

1988 • 57 citations

Interaction of a peptide model of a hydrophobic transmembrane alpha-helical segment of a membrane protein with phosphatidylethanolamine bilayers: differential scanning calorimetric and Fourier transform infrared spectroscopic studies

1995 • 56 citations

Effects of lipid fatty acyl chain structure on the activity of the (Ca2+ + Mg2+)-ATPase

1986 • 56 citations

Lipid enrichment and selectivity of integral membrane proteins in two-component lipid bilayers

1993 • 55 citations

Effects of phospholipids on the function of the calcium-magnesium ATPase

1991 • 54 citations

Theory of protein-induced lateral phase separation in lipid membranes

1989 • 51 citations

Constant helical pitch of the gramicidin channel in phospholipid bilayers

1992 • 50 citations

The tryptophans of gramicidin are essential for the lipid structure modulating effect of the peptide

1985 • 47 citations

Local Dynamics of the M13 Major Coat Protein in Different Membrane-Mimicking Systems

1996 • 39 citations

Correlation between Bilayer Lipid Dynamics and Activity of the Diglucosyldiacylglycerol Synthase from Acholeplasma laidlawii Membranes

1996 • 38 citations

Membrane Thickness and Molecular Ordering in Acholeplasma laidlawii Strain A Studied by 2H NMR Spectroscopy

1994 • 36 citations

Membrane Lipid Composition and Cell Size of Acholeplasma laidlawii Strain A are Strongly Influenced by Lipid Acyl Chain Length

1995 • 35 citations

Membrane Lipid Composition and Cell Size of Acholeplasma laidlawii Strain A are Strongly Influenced by Lipid Acyl Chain Length

1995 • 34 citations

Hydrophobic mismatch in gramicidin A'/lecithin systems

1990 • 33 citations

New Aspects on Membrane Lipid Regulation in Acholeplasma laidlawii A and Phase Equilibria of Monoacyldiglucosyldiacylglycerol

1996 • 32 citations

Importance of the tryptophans of gramicidin for its lipid structure modulating activity in lysophosphatidylcholine and phosphatidylethanolamine model membranes. A comparative study employing gramicidin analogs and a synthetic α-helical hydrophobic polypeptide

1987 • 30 citations

Studies on the purified, lipid-reconstituted (Na+ + Mg2+)-ATPase from Acholeplasma laidlawii B membranes

1989 • 28 citations

A mismatch between the length of gramicidin and the lipid acyl chains is a prerequisite for HII phase formation in phosphatidylcholine model membranes

1989 • 27 citations

Functional signal peptide reduces bilayer thickness of phosphatidylcholine liposomes

1992 • 26 citations

A theoretical model for the association of amphiphilic transmembrane peptides in lipid bilayers

1997 • 26 citations

Fatty acid composition of lipids which copurify with band 3

1989 • 21 citations

Effect of acyl chain length on the structure and motion of gramicidin A in lipid bilayers

1989 • 18 citations

Experimental evidence for predicted transmembrane peptide topography: Incorporation of hydrophobic peptide α‐helical rods with an N‐terminal positive charge having a length comparable to the thickness of lipid bilayers into the membranes

1990 • 5 citations