CROSS-TALK BETWEEN BACTERIAL PATHOGENS AND THEIR HOST CELLS

The complete general secretory pathway in gram-negative bacteria

1993 • 1,668 citations

Common Virulence Factors for Bacterial Pathogenicity in Plants and Animals

1995 • 1,322 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Molecular Genetics of Plant Disease Resistance

1995 • 932 citations

Harpin, Elicitor of the Hypersensitive Response Produced by the Plant Pathogen Erwinia amylovora

1992 • 773 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

1993 • 722 citations

Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry

1993 • 663 citations

Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation.

1995 • 626 citations

Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells.

1994 • 594 citations

Regulation of fatty acid biosynthesis in Escherichia coli

1993 • 578 citations

Molecular and functional characterization of the Salmonella invasion gene invA: homology of InvA to members of a new protein family

1992 • 578 citations

Bacterial Blight of Soybean: Regulation of a Pathogen Gene Determining Host Cultivar Specificity

1989 • 574 citations

Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia

1990 • 566 citations

Translocation of a hybrid YopE‐adenylate cyclase from Yersinia enterocolitica into HeLa cells

1994 • 532 citations

Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium.

1967 • 532 citations

Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border

1985 • 525 citations

Enteropathogenic Escherichia coli

1992 • 510 citations

Pseudomonas syringae pv. syringae harpinPss: A protein that is secreted via the hrp pathway and elicits the hypersensitive response in plants

1993 • 504 citations

The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.

1990 • 467 citations

Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach.

1995 • 465 citations

Gene cluster of Pseudomonas syringae pv. "phaseolicola" controls pathogenicity of bean plants and hypersensitivity of nonhost plants

1986 • 443 citations

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.

1991 • 393 citations

Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption

1991 • 376 citations

The cytotoxic protein YopE of Yersinia obstructs the primary host defence

1990 • 372 citations

Signal transduction in the mammalian cell during bacterial attachment and entry

1993 • 364 citations

The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD.

1994 • 362 citations

Protein secretion in Bacillus species

1993 • 352 citations

hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes

1995 • 350 citations

A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant

1993 • 350 citations

Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells

1991 • 349 citations

Membrance traffic wardens and protein secretion in Gram-negative bacteria

1993 • 346 citations

Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake.

1992 • 328 citations

Salmonella Interactions with Polarized Human Intestinal Caco-2 Epithelial Cells

1990 • 325 citations

Inhibition of phagocytosis in Yersinia pseudotuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein

1988 • 322 citations

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

1992 • 316 citations

Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation

1991 • 311 citations

The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins

1994 • 311 citations

Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica

1991 • 301 citations

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

1994 • 298 citations

Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling

1990 • 296 citations

Genetic basis of virulence in Shigella species

1991 • 293 citations

Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells

1995 • 279 citations

Identification of a putative alternate sigma factor and characterization of a multicomponent regulatory cascade controlling the expression of Pseudomonas syringae pv. syringae Pss61 hrp and hrmA genes

1994 • 275 citations

Individual chaperones required for Yop secretion by Yersinia.

1994 • 272 citations

Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.

1993 • 269 citations

Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium

1994 • 264 citations

Homology between virF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator

1989 • 263 citations

Signal transduction and invasion of epithelial cells by S. typhimurium

1993 • 260 citations

EspA, a protein secreted by enteropathogenic Escherichia coli, is required to induce signals in epithelial cells

1996 • 259 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells.

1995 • 252 citations

The surface‐located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis

1991 • 251 citations

Cell‐surface‐bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell

1995 • 246 citations

MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri Ipa invasins

1993 • 245 citations

A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurlum

1996 • 240 citations

PopA1, a protein which induces a hypersensitivity-like response on specific Petunia genotypes, is secreted via the Hrp pathway of Pseudomonas solanacearum.

1994 • 238 citations

Temperature-dependent expression of virulence genes in Shigella species

1984 • 237 citations

YscN, the putative energizer of the Yersinia Yop secretion machinery

1994 • 236 citations

Plant and environmental sensory signals control the expression of hrp genes in Pseudomonas syringae pv. phaseolicola

1992 • 235 citations

IpaB mediates macrophage apoptosis induced by Shigella flexneri

1994 • 228 citations

Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins

1995 • 227 citations

Conservation of secretion pathways for pathogenicity determinants of plant and animal bacteria

1993 • 226 citations

Involvement of the epidermal growth factor receptor in the invasion of cultured mammalian cells by Salmonella typhimurium

1992 • 224 citations

Internal Lysine Palmitoylation in Adenylate Cyclase Toxin from Bordetella pertussis

1994 • 223 citations

Nucleotide sequence of the leukotoxin genes of Pasteurella haemolytica A1

1987 • 218 citations

Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium

1990 • 217 citations

Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells

1992 • 215 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

Yops of Yersinia spp. pathogenic for humans

1993 • 209 citations

Customized secretion chaperones in pathogenic bacteria

1996 • 209 citations

The hrp gene locus of Pseudomonas solanacearum, which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complex

1995 • 207 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae.

1995 • 205 citations

SycE, a chaperone‐like protein of Yersinia enterocolitica involved in the secretion of YopE

1993 • 204 citations

The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells.

1996 • 200 citations

A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence‐associated antigens of Shigella flexneri

1989 • 199 citations

Enhanced secretion through the Shigella flexneri Mxi‐Spa translocon leads to assembly of extracellular proteins into macromolecular structures

1995 • 199 citations

Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells.

1992 • 197 citations

PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion

1995 • 195 citations

YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice

1990 • 195 citations

Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells

1995 • 190 citations

Passive immunity to yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide

1994 • 190 citations

LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response

1991 • 189 citations

Fatty Acylation of Two Internal Lysine Residues Required for the Toxic Activity of Escherichia coli Hemolysin

1994 • 188 citations

Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus

1992 • 183 citations

A superfamily of proteins involved in different secretion pathways in gram-negative bacteria: modular structure and specificity of the N-terminal domain

1994 • 182 citations

Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway.

1995 • 181 citations

YopB and YopD constitute a novel class of Yersinia Yop proteins

1993 • 179 citations

Evidence that the hrpB gene encodes a positive regulator of pathogenicity genes from Pseudomonas solanacearum

1992 • 178 citations

Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells.

1995 • 174 citations

Capturing host plasmin(ogen): a common mechanism for invasive pathogens?

1994 • 174 citations

Determinants of Pathogenicity inXanthomonas campestrispv.vesicatoriaare Related to Proteins Involved in Secretion in Bacterial Pathogens of Animals

1992 • 174 citations

MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins

1992 • 172 citations

A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH

1992 • 170 citations

Molecular and functional characterization of the Salmonella typhimurium invasion genes invB and invC: homology of InvC to the F0F1 ATPase family of proteins

1994 • 168 citations

Contact of Shigella with host cells triggers release of Ipa invasins and is an essential function of invasiveness.

1995 • 168 citations

The Yersinia pseudotuberculosis adhesin YadA mediates intimate bacterial attachment to and entry into HEp-2 cells

1993 • 163 citations

Elevation of intracellular free calcium levels in HEp-2 cells infected with enteropathogenic Escherichia coli

1991 • 160 citations

Prokaryotic plant parasites

1993 • 160 citations

Expression of Erwinia amylovora hrp genes in response to environmental stimuli

1992 • 159 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Requirement for exported proteins in secretion through the invasion-associated type III system of Salmonella typhimurium

1996 • 152 citations

The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium

1994 • 151 citations

Cloning and Characterization of a Hemolysin Gene fromActinobacillus (Haemophilus) pleuropneumoniae

1989 • 150 citations

hrpL activates Erwinia amylovora hrp gene transcription and is a member of the ECF subfamily of sigma factors

1995 • 148 citations

YscU, a Yersinia enterocolitica inner membrane protein involved in Yop secretion

1994 • 147 citations

Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase

1995 • 146 citations

The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophage.

1992 • 142 citations

Analysis of the role of the Pseudomonas syringae pv. syringae HrpZ harpin in elicitation of the hypersensitive response in tobacco using functionally non‐polar hrpZ deletion mutations, truncated HrpZ fragments, and hrmA mutations

1996 • 141 citations

Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a

1993 • 140 citations

Contact with cultured epithelial cells stimulates secretion of Salmonella typhimurium invasion protein InvJ

1995 • 140 citations

Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens

1991 • 137 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus

1995 • 135 citations

Salmonella invasion of nonphagocytic cells induces formation of macropinosomes in the host cell

1994 • 132 citations

hrpGenes ofPseudomonas solanacearumare Homologous to Pathogenicity Determinants of Animal Pathogenic Bacteria and are Conserved Among Plant Pathogenic Bacteria

1992 • 132 citations

Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis

1994 • 128 citations

Regulation and polarized transfer of the Yersinia outer proteins (Yops) involved in antiphagocytosis

1994 • 126 citations

The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GPIb alpha

1989 • 123 citations

The Cell Biology of Infection by Intracellular Bacterial Pathogens

1995 • 123 citations

mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis

1992 • 122 citations

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

1995 • 120 citations

Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism.

1993 • 120 citations

Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica.

1995 • 117 citations

A diarrheal pathogen, enteropathogenic Escherichia coli (EPEC), triggers a flux of inositol phosphates in infected epithelial cells.

1994 • 117 citations

The Pseudomonas syringae pv. syringae 61 hrpH product, an envelope protein required for elicitation of the hypersensitive response in plants

1992 • 116 citations

Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestis

1995 • 112 citations

Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells.

1995 • 112 citations

Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression

1995 • 106 citations

Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis

1995 • 105 citations

Moving through the membrane with filamentous phages

1995 • 105 citations

Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages

1987 • 104 citations

The CompletehrpGene Cluster ofPseudomonas syringaepv.syringae61 Includes Two Blocks of Genes Required for Harpin_PssSecretion that Are Arranged Colinearly withYersinia yscHomologs

1995 • 102 citations

Genetic and biochemical analysis of Salmonella typhimurium FliI, a flagellar protein related to the catalytic subunit of the F0F1 ATPase and to virulence proteins of mammalian and plant pathogens

1993 • 101 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

The secretion pathway of IgA protease‐type proteins in gram‐negative bacteria

1993 • 98 citations

The hrpRS locus of Pseudomonas syringae pv. phaseolicola constitutes a complex regulatory unit

1995 • 98 citations

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus

1993 • 97 citations

Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis

1989 • 96 citations

Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388.

1994 • 95 citations

Cloning determinants of pathogenesis from Pseudomonas syringae pathovar syringae

1985 • 93 citations

Functional conservation among members of the Salmonella typhimurium InvA family of proteins

1995 • 91 citations

Yersinia pestis YopM: thrombin binding and overexpression

1992 • 87 citations

DNA sequence and product analysis of the virF locus responsible for congo red binding and cell invasion in Shigella flexneri 2a

1986 • 86 citations

Salmonella typhimurium invasion of epithelial cells: role of induced host cell tyrosine protein phosphorylation

1994 • 85 citations

Shigella subversion of the cellular cytoskeleton: a strategy for epithelial colonization

1993 • 84 citations

Salmonella typhimuriuminduces an inositol phosphate flux in infected epithelial cells

1992 • 83 citations

Identification of a novel virulence gene, virA, on the large plasmid of Shigella, involved in invasion and intercellular spreading

1995 • 83 citations

The mechanism of secretion of hemolysin and other polypeptides from Gram-negative bacteria

1990 • 81 citations

A pleiotropic reduced virulence (Rvi^‐) mutant of Erwinia carotovora subspecies atroseptica is defective in flagella assembly proteins that are conserved in plant and animal bacterial pathogens

1993 • 79 citations

Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica

1994 • 79 citations

The general protein‐export pathway is directly required for extracellular pullulanase secretion in Escherichia coli k12

1991 • 76 citations

A pleiotropic reduced virulence (Rvi⁻) mutant of Erwinia carotovora subspecies atroseptica is defective in flagella assembly proteins that are conserved in plant and animal bacterial pathogens

1993 • 68 citations

Plasmid-determined cytotoxicity in Yersinia pestis and Yersinia pseudotuberculosis

1986 • 61 citations

Structure and regulation of the Yersinia pestis yscBCDEF operon

1992 • 57 citations

Nucleotide sequence of iagA and iagB genes involved in invasion of HeLa cells by Salmonella enterica subsp. enterica ser. Typhi

1995 • 53 citations

The low-Ca2+ response virulence regulon of human-pathogenic yersiniae

1991 • 50 citations

Homology between the HrpO protein of Pseudomonas solanacearum and bacterial proteins implicated in a signal peptide-independent secretion mechanism

1993 • 50 citations

Calcium-calmodulin dependence of actin accretion and lethality in cultured HEp-2 cells infected with enteropathogenic Escherichia coli

1993 • 49 citations

Characterization of thePseudomonas syringaepv.syringae61hrpJandhrpIGenes: Homology of HrpI to a Superfamily of Proteins Associated with Protein Translocation

1993 • 47 citations

Purification of a 20 kDa phosphoprotein from epithelial cells and identification as a myosin light chain Phosphorylation induced by enteropathogenicEscherichia coli and phorbol ester

1991 • 44 citations

Characterization of thehrpJandhrpUOperons ofPseudomonas syringaepv.syringaePss61: Similarity with Components of Enteric Bacteria Involved in Flagellar Biogenesis and Demonstration of Their Role in Harpin_PssSecretion

1994 • 43 citations

Carbon dioxide regulated secretion of the EaeB protein of enteropathogenicEscherichia coli

1995 • 43 citations

Microbial recognition and activation of plant defense systems

1993 • 39 citations

EFFECT OF CYTOCHALASIN B AND DI‐HYDROCYTOCHALASIN B ON INVASIVENESS OF ENTERO‐INVASIVE BACTERIA IN HEp‐2 CELL CULTURES

1984 • 29 citations

Salmonella typhimurium induces an inositol phosphate flux in infected epithelial cells

1992 • 10 citations

Nucleotide sequence and transcriptional regulation of a positive regulatory gene of Shigella dysenteriae

1992 • 8 citations

Yops of the PathogenicYersiniaspp.

2014 • 6 citations

Carbon dioxide regulated secretion of the EaeB protein of enteropathogenic

1995 • 4 citations

Extracellular Proteins as Determinants of Pathogenicity in Pseudomonas syringae

1997 • 2 citations