Contact of Shigella with host cells triggers release of Ipa invasins and is an essential function of invasiveness.

Mechanism of Assembly of the Outer Membrane of Salmonella typhimurium

1972 • 1,574 citations

Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector

1991 • 1,062 citations

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

1993 • 722 citations

A new and improved microassay to determine 2-keto-3-deoxyoctonate in lipopolysaccharide of gram-negative bacteria

1978 • 701 citations

EPITHELIAL CELL PENETRATION AS AN ESSENTIAL STEP IN THE PATHOGENESIS OF BACILLARY DYSENTERY

1964 • 628 citations

Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells.

1994 • 594 citations

The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD.

1994 • 362 citations

Membrance traffic wardens and protein secretion in Gram-negative bacteria

1993 • 346 citations

Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation

1987 • 327 citations

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

1992 • 316 citations

Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole

1992 • 315 citations

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

1994 • 298 citations

Genetic basis of virulence in Shigella species

1991 • 293 citations

Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.

1993 • 269 citations

MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri Ipa invasins

1993 • 245 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

Conservation of secretion pathways for pathogenicity determinants of plant and animal bacteria

1993 • 226 citations

Molecular alteration of the 140-megadalton plasmid associated with loss of virulence and Congo red binding activity in Shigella flexneri

1986 • 212 citations

Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri.

1994 • 207 citations

A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence‐associated antigens of Shigella flexneri

1989 • 199 citations

Virulence-associated genetic regions comprising 31 kilobases of the 230-kilobase plasmid in Shigella flexneri 2a

1988 • 195 citations

Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus

1992 • 183 citations

MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins

1992 • 172 citations

The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium

1994 • 151 citations

Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells

1987 • 149 citations

YscU, a Yersinia enterocolitica inner membrane protein involved in Yop secretion

1994 • 147 citations

Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a

1993 • 140 citations

Molecular cloning of invasion plasmid antigen (ipa) genes from Shigella flexneri: analysis of ipa gene products and genetic mapping

1987 • 139 citations

Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens

1991 • 137 citations

Regulation and polarized transfer of the Yersinia outer proteins (Yops) involved in antiphagocytosis

1994 • 126 citations

mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis

1992 • 122 citations

Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri.

1988 • 121 citations

Expression of four virulence antigens of Shigella flexneri is positively regulated at the transcriptional level by the 30 kilo Dalton virF protein

1988 • 118 citations

Functional organization and nucleotide sequence of virulence Region-2 on the large virulence plasmid in Shigella flexneri 2a

1989 • 114 citations

Release of Surface Enzymes in Enterobacteriaceae by Osmotic Shock

1967 • 112 citations

A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis

1994 • 111 citations

Shigella flexneri invasion plasmid antigens B and C: epitope location and characterization with monoclonal antibodies

1988 • 104 citations

Fractionation of Rhizobium leguminosarum cells into outer membrane, cytoplasmic membrane, periplasmic, and cytoplasmic components

1986 • 90 citations

Identification and characterization of virK, a virulence‐associated large plasmid gene essential for intercellular spreading of Shigella flexneri

1992 • 83 citations

Nucleotide sequence of the invasion plasmid antigen B and C genes (ipaB and ipaC) of Shigella flexneri

1988 • 79 citations

Identification of Shigella invasion genes by isolation of temperature-regulated inv::lacZ operon fusions

1989 • 65 citations

The Large Virulence Plasmid of Shigella

1992 • 51 citations

In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli

1983 • 50 citations

IS50-mediated inverse transposition

1982 • 50 citations