Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER

1974 • 840 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases

1988 • 480 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

1993 • 375 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

1993 • 297 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.

1994 • 248 citations

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

1992 • 208 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

The subcellular distribution of early endosomes is affected by the annexin II2p11(2) complex.

1993 • 157 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.

1993 • 153 citations

Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport ¹

1990 • 151 citations

Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines

1993 • 149 citations

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein

1993 • 147 citations

A 190-Kilodalton Protein Overexpressed in Non-P-Glycoprotein-Containing Multidrug-Resistant Cells and Its Relationship to the MRP Gene

1994 • 143 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein

1987 • 122 citations

Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.

1988 • 121 citations

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

1990 • 116 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Elevated expression of Annexin II (Lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line

1992 • 97 citations

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

1992 • 94 citations

Mechanisms of membrane protein turnover

1990 • 73 citations

Subfractionation of hepatic endosomes in Nycodenz gradients and by free-flow electrophoresis. Separation of ligand-transporting and receptor-enriched membranes

1985 • 70 citations

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression

1991 • 66 citations

L-Pipecolate oxidase: A distinct peroxisomal enzyme in man

1989 • 63 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations

Differences between the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasts reside primarily at the translational and post-translational levels.

1991 • 54 citations

Isolation of the major subcellular organelles from mouse liver using Nycodenz gradients without the use of an ultracentrifuge

1990 • 52 citations

Mechanisms of plasma membrane protein degradation: recycling proteins are degraded more rapidly than those confined to the cell surface.

1991 • 52 citations

Non-P-glycoprotein-mediated multidrug resistance with reduced EGF receptor expression in a human large cell lung cancer cell line

1990 • 48 citations

Annexins in the endocytic pathway

1994 • 47 citations

Strategies for the purification of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1991 • 38 citations

Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiationin vitro

1993 • 31 citations

NADP phosphatase as a marker in free-flow electrophoretic separations for cisternae of the Golgi apparatus midregion

1986 • 31 citations

Separation of endocytic vesicles in Nycodenz gradients

1984 • 27 citations

Reduced levels of topoisomerase II? and II? in a multidrug-resistant lung-cancer cell line

1994 • 25 citations

A solubilisable polymer support suitable for solid phase peptide synthesis and for injection into experimental animals

1988 • 15 citations

Induction of alkaline phosphatase activity in HeLa cells by choline chloride.

1978 • 11 citations

[36] Growth factor effects on membrane transport: uptake studies using cell cultures and isolated membrane vesicles

1987 • 7 citations