The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway

1990 • 972 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1991 • 689 citations

Submucosal glands are the predominant site of CFTR expression in the human bronchus

1992 • 644 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Cystic fibrosis: a disease in electrolyte transport

1990 • 510 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1991 • 498 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland

1992 • 354 citations

Regulation of Plasma Membrane Recycling by CFTR

1992 • 339 citations

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

1991 • 296 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.

1992 • 240 citations

Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation

1992 • 214 citations

Post-Golgi membrane traffic: brefeldin A inhibits export from distal Golgi compartments to the cell surface but not recycling.

1992 • 204 citations

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

1991 • 196 citations

CFTR!

1992 • 192 citations

The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR

1993 • 187 citations

Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia.

1992 • 171 citations

Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ “leak”.

1991 • 131 citations

Differential Localization of the Cystic Fibrosis Transmembrane Conductance Regulator in Normal and Cystic Fibrosis Airway Epithelium

1992 • 128 citations

The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH.

1992 • 120 citations

Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes

1993 • 109 citations

cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.

1991 • 102 citations

The cystic fibrosis transmembrane conductance regulator. Effects of the most common cystic fibrosis-causing mutation on the secondary structure and stability of a synthetic peptide.

1992 • 92 citations

Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.

1992 • 63 citations

Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells.

1991 • 25 citations

Kinetics of the functional loss of different muscarinic receptor isoforms in Xenopus oocytes

1992 • 12 citations