Low Levels of Protein C Are Associated With Poor Outcome in Severe Sepsis

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

1997 • 797 citations

Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

1992 • 708 citations

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

1996 • 524 citations

Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects

1989 • 487 citations

Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)

1992 • 479 citations

A Trial of Antioxidants N-acetylcysteine and Procysteine in ARDS

1997 • 409 citations

Pathogenesis of Disseminated Intravascular Coagulation in Sepsis

1993 • 349 citations

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

1989 • 337 citations

Time Course of Hemostatic Abnormalities in Sepsis and its Relation to Outcome

1993 • 310 citations

Derangements of Coagulation and Fibrinolysis in Critically III Patients with Sepsis and Septic Shock

1998 • 300 citations

The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent

1996 • 294 citations

Disseminated Intravascular Coagulation

1999 • 233 citations

Molecular Events that Control the Protein C Anticoagulant Pathway

1993 • 223 citations

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

2000 • 206 citations

Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

1989 • 202 citations

Complement Activation and Endotoxin Levels in Systemic Meningococcal Disease

1989 • 201 citations

Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients

1996 • 196 citations

Coagulation Activation and Tissue Necrosis in Meningococcal Septic Shock: Severely Reduced Protein C Levels Predict a High Mortality

1995 • 190 citations

Direct detection of activated protein C in blood from human subjects

1992 • 179 citations

The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide a in systemic meningococcal disease

1989 • 172 citations

Coagulation, fibrinolysis, and kallikrein systems in sepsis

1989 • 159 citations

STORED RED BLOOD CELLS SELECTIVELY ACTIVATE HUMAN NEUTROPHILS TO RELEASE IL-8 AND SECRETORY PLA2

2000 • 159 citations

Epidemic Meningococcemia and Purpura Fulminans with Induced Protein C Deficiency

1993 • 154 citations

Direct detection of activated protein C in blood from human subjects

1992 • 151 citations

Protein C, protein S and C4b-binding protein in severe infection and septic shock.

1991 • 145 citations

Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases

1992 • 136 citations

Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?

2000 • 133 citations

Modulators of coagulation. A critical appraisal of their role in sepsis

1992 • 124 citations

Endothelial Protein C Receptor

1999 • 115 citations

Changes of the hemostatic network in critically ill patients-Is there a difference between sepsis, trauma, and neurosurgery patients?

2000 • 110 citations

Protein C, Protein S and c4b-Binding Protein in Severe lnfection and Septic Shock

1991 • 107 citations

Regulation and functions of the protein C anticoagulant pathway.

1999 • 92 citations

Age-related Differences in Outcome and Severity of DIC in Children with Septic Shock and Purpura

1996 • 84 citations

Fibrinolysis and Coagulation in Patients with Infectious Disease and Sepsis

1991 • 80 citations

Modulators of Coagulation

1992 • 75 citations

Coagulation/Fibrinolysis Balance in Septic Shock Related to Cytokines and Clinical State

1994 • 55 citations

Immunobiology and Therapeutic Applications of Protein C/Protein S/Thrombomodulin in Human and Experimental Allotransplantation and Xenotransplantation

1997 • 20 citations

A monoclonal-antibody-based radioimmunoassay for measurement of protein C in plasma.

1988 • 16 citations

Chapter 11. Antithrombotic and Anti-Inflammatory Agents of The Protein C Anticoagulant Pathway

1994 • 15 citations

Severe Protein C Deficiency, Predictor of Lethal Outcome in Meningococcal Septicaemia

1999 • 4 citations

Prevalence of Factor V 1691A (FV Leiden) and Prothrombin 20210A Allele in Children

1999 • 3 citations