Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Gram-Negative Bacteremia

1962 • 1,375 citations

Gram-negative bacteremia

1980 • 1,341 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Cultured human endothelial cells generate tissue factor in response to endotoxin.

1983 • 516 citations

Evidence for a rapid inhibitor to tissue plasminogen activator in plasma

1983 • 479 citations

Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.

1986 • 414 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma

1984 • 382 citations

Deficient t-PA Release and Elevated PA Inhibitor Levels in Patients with Spontaneous or Recurrent Deep Venous Thrombosis

1987 • 373 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

1985 • 341 citations

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

1986 • 326 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 300 citations

Treatment of Gram-Negative Septic Shock with Human IgG Antibody to Escherichia coli J5: A Prospective, Double-Blind, Randomized Trial

1988 • 266 citations

Septic shock. Hemodynamics and pathogenesis.

1983 • 229 citations

Plasminogen activator inhibitor 1: development of a radioimmunoassay and observations on its plasma concentration during venous occlusion and after platelet aggregation

1987 • 195 citations

Studies on the Release of a Plasminogen Activator Inhibitor by Human Platelets

1986 • 152 citations

Recombinant human tumor necrosis factor‐α: Thrombus formation is a cause of anti‐tumor activity

1988 • 110 citations

Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes.

1988 • 105 citations

Endotoxin induction of an inhibitor of plasminogen activator in bovine pulmonary artery endothelial cells.

1986 • 85 citations

Blood coagulation and fibrinolytic factors and their inhibitors in critically ill patients

1984 • 75 citations

Extreme plasminogen activator inhibitor and endotoxin values in patients with meningococcal disease

1986 • 65 citations

Studies of components of the coagulation systems in normal individuals and septic shock patients.

1982 • 55 citations

Plasminogen activator inhibitor: a regulator of ancrod-induced fibrin deposition in rabbits

1987 • 46 citations

Renal Cortical Fibrinolytic Activity in the Rabbit Following One or Two Doses of Endotoxin

1973 • 34 citations

Effect of polymyxin B and colimycin on induction of plasminogen antiactivator by lipopolysaccharide in human endothelial cell culture

1986 • 26 citations

Changes in the fibrinolytic enzyme system following intravascular coagulation induced by thrombin and endotoxin

1968 • 23 citations