Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta

Principles and procedures of statistics.

1960 • 22,587 citations

Principles and Procedures of Statistics

1961 • 18,011 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

[66] Pyruvate kinase from muscle

1955 • 724 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

1977 • 625 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

VITAMIN E AND FREE RADICAL PEROXIDATION OF LIPIDS*

1972 • 471 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Recovery of Endothelial Cell Prostacyclin Production after Inhibition by Low Doses of Aspirin

1979 • 310 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits

1977 • 287 citations

Metabolism of prostaglandin endoperoxide in animal tissues

1977 • 287 citations

SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN

1979 • 279 citations

Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits

1978 • 256 citations

Studies of the mechanism of vitamin E action. IV. Lipide peroxidation in the vitamin E-deficient rabbit

1960 • 242 citations

Vitamin E and Lipid Metabolism in Man

1960 • 236 citations

Quantitative Consideration of the Effect of Polyunsaturated Fatty Acid Content of the Diet Upon the Requirements for Vitamin E

1963 • 211 citations

Effect of dietary vitamin E on expiration of pentane and ethane by the rat

1977 • 206 citations

Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.

1978 • 196 citations

Effects of Limited Tocopherol Intake in Man with Relationships to Erythrocyte Hemolysis and Lipid Oxidations

1956 • 189 citations

Radioimmunoassays of Prostaglandins and Thromboxanes

1977 • 177 citations

Lipid Peroxidation in Vivo during Vitamin E and Selenium Deficiency in the Rat as Monitored by Ethane Evolution

1977 • 175 citations

VITAMIN E AND THE BIOLOGICAL ANTIOXIDANT THEORY

1972 • 126 citations

Use of a radioimmunoassay to study thrombin-induced release of PGI2 from cultured endothelium

1979 • 123 citations

Generation of prostacyclin-like substance and lipid peroxidation in vitamin E-deficient rats

1980 • 115 citations

Inhibition of prostacyclin by treatment of endothelium with aspirin. Correlation with platelet adherence.

1979 • 114 citations

Effects of intravenous infusion of prostacyclin (PGI2) in man

1980 • 111 citations

A function for α‐tocopherol: Stabilization of the microsomal membrane from radical attack during TPNH‐dependent oxidations

1971 • 98 citations

Biosynthesis of prostaglandins in rabbit kidney medulla. Properties of prostaglandin synthase

1976 • 84 citations

Oxidative biotransformations of arachidonic acid

1977 • 52 citations

The effect of antioxidant deficiency on tissue lipid composition in the rat. I. Gastrocnemius and quadriceps muscle

1967 • 44 citations

The effect of antioxidant deficiency on tissue lipid composition in the rat. II. Liver

1967 • 40 citations

Plasma Activity of Pyruvate Kinase and Glutamic Oxalacetic Transaminase as Indices of Myopathy in the Vitamin E Deficient Rat

1978 • 36 citations

The Effects of Vitamin E Depletion and Repletion on Prostaglandin Synthesis in Semitendinosus Muscle of Young Rabbits

1980 • 34 citations

Increased Activity of Pyruvate Kinase in Plasma of Vitamin E-deficient Rats

1975 • 27 citations

Radioimmunoassays for prostaglandins. I. Technical validation of prostaglandin F2α measurements in human plasma using Sephadex G-25 gelfiltration

1978 • 20 citations

Radioimmunoassays for prostaglandins. II. Measurement of prostaglandin E2 and the 13,14-dihydro-15-keto metabolites of the E and F series. Description of a reliable technique with a universal applicability

1978 • 19 citations

The use of dextran-coated charcoal for kinetic measurements: Interaction between rifampicin and DNA-dependent RNA polymerase ofEscherichia coli

1976 • 17 citations

The effects of vitamin E and indomethacin on blood creatine Phosphokinase and fatty acid composition of tissues from young rabbits

1979 • 11 citations

Effect of low and high methional concentrations on prostaglandin biosynthesis in microsomes from bovine and sheep vesicular glands

1979 • 8 citations