Genetic Variation in the Renin–Angiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1985 • 29,733 citations

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

1991 • 2,314 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)

1992 • 1,280 citations

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

1992 • 1,181 citations

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

1995 • 920 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

The Search for Human Obesity Genes

1998 • 570 citations

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.

1997 • 547 citations

Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

2000 • 467 citations

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

1997 • 443 citations

Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction

1994 • 421 citations

The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk

1997 • 400 citations

Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension

1992 • 386 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II¹

1998 • 330 citations

Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease

1995 • 310 citations

Angiotensin II Increases Lipogenesis in 3T3-L1 and Human Adipose Cells*

1997 • 301 citations

Genetics of Obesity

1993 • 247 citations

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

1995 • 245 citations

M235T angiotensinogen gene polymorphism and cardiovascular renal risk

1999 • 236 citations

Genome Scan for Human Obesity and Linkage to Markers in 20q13

1999 • 232 citations

Co-expression of renin-angiotensin system genes in human adipose tissue

1999 • 230 citations

Rapid detection of the hypertension-associated Met²³⁵→ Thr allele of the human angiotensinogen gene

1993 • 208 citations

Uric acid metabolism and tubular sodium handling. Results from a population-based study

1993 • 205 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.

1994 • 197 citations

Association Between the Angiotensinogen 235T-Variant and Essential Hypertension in Whites

1997 • 195 citations

Autosomal Genomic Scan for Loci Linked to Obesity and Energy Metabolism in Pima Indians

1998 • 182 citations

Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control

1997 • 179 citations

Meta-analysis of the ACE gene in ischaemic stroke

1998 • 174 citations

Plasma Angiotensinogen Concentrations in Obese Patients

1997 • 169 citations

ACE, angiotensinogen and obesity: a potential pathway leading to hypertension

1997 • 165 citations

Evidence for a local renin angiotensin system in primary cultured human preadipocytes

1999 • 159 citations

Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering.

1994 • 115 citations

Insulin-Resistant Lipolysis in Abdominally Obese Hypertensive Individuals

1996 • 103 citations

Renin-Angiotensin System Gene Polymorphisms, Blood Pressure,Dyslipidemia, and Diabetes in Hong Kong Chinese

2001 • 102 citations

Angiotensinogen, angiotensin II and adipose tissue development

2000 • 100 citations

Central Obesity and Hypertension: Relationship Between Fasting Serum Insulin, Plasma Renin Activity, and Diastolic Blood Pressure in Young Obese Subjects

1994 • 96 citations

Angiotensinogen levels and obesity in four black populations

1998 • 88 citations

Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study

2001 • 79 citations

The insertion/deletion polymorphism of the angiotensin-converting enzyme gene and car-diovascular-renal risk : a meta-analysis

1997 • 59 citations

Converting Enzyme Inhibition and Its Withdrawal in Spontaneously Hypertensive Rats

1995 • 53 citations

The Insertion/Deletion Polymorphism of the ACE Gene Is Related to Insulin Sensitivity in Overweight Women

2001 • 53 citations

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

2001 • 45 citations

Developmental aspects of the Adipose tissue renin‐angiotensin system: Therapeutic implications

1994 • 43 citations

Hunting for human obesity genes? Look in the adipose tissue!

2000 • 34 citations