Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1985 • 29,733 citations

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

1991 • 2,314 citations

Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.

1998 • 843 citations

Relationship Between Resistance to Insulin-Mediated Glucose Uptake, Urinary Uric Acid Clearance, and Plasma Uric Acid Concentration

1991 • 786 citations

Association of a Polymorphism in the β₃-Adrenergic–Receptor Gene with Features of the Insulin Resistance Syndrome in Finns

1995 • 552 citations

Tissue distribution of beta 3-adrenergic receptor mRNA in man.

1993 • 521 citations

Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: Visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity

1998 • 337 citations

A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.

1995 • 247 citations

Genetics of Obesity

1993 • 247 citations

Uric acid metabolism and tubular sodium handling. Results from a population-based study

1993 • 205 citations

Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration

1991 • 202 citations

Distribution of β3-adrenoceptor mRNA in human tissues

1995 • 154 citations

Evidence for a functional β₃‐adrenoceptor in man

1993 • 148 citations

The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.

1996 • 144 citations

Demonstration of an in vivo functional beta 3-adrenoceptor in man.

1995 • 134 citations

b 3 -adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome

1997 • 132 citations

Meta-analysis of the association of the Trp64Arg polymorphism in the β3 adrenergic receptor with body mass index

1998 • 128 citations

The Biochemical Effect of the Naturally Occurring Trp644→Arg Mutation on Human β3‐Adrenoceptor Activity

1997 • 125 citations

Adrenoceptor genes in human obesity

1999 • 122 citations

Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.

1999 • 115 citations

Insulin Sensitivity and Body Weight Changes in Young White Carriers of the Codon 64 Amino Acid Polymorphism of the β3-Adrenergic Receptor Gene

1996 • 114 citations

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations

1996 • 103 citations

Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs

1999 • 101 citations

Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

1997 • 95 citations

The Evidence for a Pathophysiologic Significance of the Sympathetic Overactivity in Hypertension

1996 • 93 citations

Expression of beta3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes.

1996 • 89 citations

Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

1996 • 89 citations

The β3-Adrenergic Receptor Gene Trp64Arg Mutation is Overrepresented in Obese Women: Effects on Weight, BMI, Abdominal Fat, Blood Pressure, and Reproductive History in an Elderly Australian Population

1996 • 82 citations

Hyperinsulinaemia, obesity, and syndrome X

1994 • 78 citations

The Trp64Arg Polymorphism of the β 3-Adrenergic Receptor Gene Is Not Associated with Obesity or Type 2 Diabetes Mellitus in a Large Population-Based Caucasian Cohort

1998 • 77 citations

Relation of abdominal obesity to hyperinsulinemia and high blood pressure in men.

1992 • 72 citations

Peripheral vascular effects of beta-3 adrenergic receptor stimulation in conscious dogs.

1994 • 71 citations

Beta-3 adrenoceptor-mediated increase in cutaneous blood flow in the dog.

1994 • 64 citations

Effects of age and hypertension on autonomic nervous regulation during passive head-up tilt.

1994 • 61 citations

The Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndrome

1997 • 51 citations

Early Association of Sympathetic Overactivity, Hypertension, Insulin Resistance, and Coronary Risk

1992 • 50 citations

Prevalence of the Trp64Arg missense mutation of the β3-adrenergic receptor gene in Japanese subjects

1997 • 48 citations

Frequency and significance of the A→G (−3826) polymorphism in the promoter of the gene for uncoupling protein‐1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population‐based Caucasian cohort

1999 • 47 citations

Cardiovascular regulation in obesity-induced hypertension.

1992 • 45 citations

Antibodies for the Immunochemistry of the Human β3‐Adrenergic Receptor

1994 • 45 citations

Multigenic human hypertension: evidence for subtypes and hope for haplotypes.

1990 • 44 citations

The Association between Trp⁶⁴Arg Polymorphism of the β₃-Adrenergic Receptor and Autonomic Nervous System Activity¹

1999 • 43 citations

The W64R variant of the β 3 -adrenergic receptor is not associated with Type II diabetes or obesity in a large Finnish sample

1999 • 42 citations

Pharmacological characterization of a recently described human beta 3- adrenergic receptor mutant

1996 • 41 citations

Phenotypic characterization of the β3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men

1999 • 38 citations

Trp64Arg Mutation of ?-Adrenergic Receptor in Essential Hypertension Insulin Resistance and the Adrenergic System

1997 • 37 citations

Association of Trp64Arg β3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population

1999 • 34 citations

Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the beta 3-adrenergic receptor gene

1996 • 32 citations

The Trp64Arg Polymorphism of the 3-Adrenergic Receptor Gene Is Not Associated with Obesity or Type 2 Diabetes Mellitus in a Large Population-Based Caucasian Cohort

1998 • 31 citations

The independent effects of obesity and body fat distribution on blood pressure in black adults: the Pitt County study.

1993 • 30 citations

Association of β3-Adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men

1999 • 29 citations

No effect of the Trp64Arg β 3 -adrenoceptor variant on in vivo lipolysis in subcutaneous adipose tissue

1997 • 25 citations

The codon 64 polymorphism of the β3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients

1999 • 22 citations

The Association between Trp64Arg Polymorphism of the 3-Adrenergic Receptor and Autonomic Nervous System Activity

1999 • 22 citations

Relation of β3-adrenergic receptor gene mutation to total body fat but not percent body fat and insulin levels in Thais

1999 • 17 citations

Treatment of the elderly hypertensive patient

1990 • 17 citations

Analysis of Candidate Genes for Insulin Resistance in Essential Hypertension

1996 • 17 citations

Lack of association between genetic variation in the β3-adrenergic receptor gene and insulin resistance in patients with coronary heart disease

1999 • 15 citations

The beta 3-adrenergic receptor gene Trp64Arg mutation is overrepresented in obese women. Effects on weight, BMI, abdominal fat, blood pressure, and reproductive history in an elderly Australian population

1996 • 14 citations