M235T angiotensinogen gene polymorphism and cardiovascular renal risk

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Molecular basis of human hypertension: Role of angiotensinogen

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Linkage of the Angiotensinogen Gene to Essential Hypertension

1994 • 579 citations

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.

1997 • 547 citations

A molecular variant of angiotensinogen associated with preeclampsia

1993 • 505 citations

Meta-analysis: State-of-the-Science

1992 • 504 citations

The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk

1997 • 400 citations

Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.

1997 • 319 citations

Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease

1995 • 310 citations

Haplotypes of Angiotensinogen in Essential Hypertension

1997 • 285 citations

Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes

1993 • 264 citations

Angiotensinogen as a risk factor for essential hypertension in Japan.

1994 • 258 citations

Rapid detection of the hypertension-associated Met²³⁵→ Thr allele of the human angiotensinogen gene

1993 • 208 citations

Association Between the Angiotensinogen 235T-Variant and Essential Hypertension in Whites

1997 • 195 citations

Angiotensin I converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus

1996 • 195 citations

Angiotensin converting enzyme gene polymorphism: Potential silencer motif and impact on progression in IgA nephropathy

1996 • 193 citations

Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.

1995 • 193 citations

Angiotensinogen gene in human hypertension. Lack of an association of the 235T allele among African Americans.

1994 • 169 citations

ACE, angiotensinogen and obesity: a potential pathway leading to hypertension

1997 • 165 citations

Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity

1996 • 156 citations

A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate.

1994 • 144 citations

Structure of Human Angiotensinogen Gene

1989 • 132 citations

Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter.

1990 • 132 citations

Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke

1998 • 128 citations

Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.

1997 • 125 citations

Molecular Variant of Angiotensinogen Gene Is Associated With Coronary Atherosclerosis

1995 • 123 citations

Cross-Sectional Analysis of Met235→Thr Variant of Angiotensinogen Gene in Severe, Familial Hypertension

1993 • 123 citations

Angiotensinogen Gene and Blood Pressure in the Japanese Population

1995 • 114 citations

Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese.

1994 • 113 citations

Enhanced Predictability of Myocardial Infarction in Japanese by Combined Genotype Analysis

1995 • 109 citations

Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes

1996 • 107 citations

Variation at the Angiotensin-Converting Enzyme Gene and Angiotensinogen Gene Loci in Relation to Blood Pressure

1996 • 105 citations

Polymorphisms of Renin-Angiotensin Genes Among Nigerians, Jamaicans, and African Americans

1996 • 105 citations

Genetic variation at the angiotensinogen locus in relation to high blood pressure and myocardial infarction

1995 • 101 citations

Hypertension, Serum Angiotensinogen, and Molecular Variants of the Angiotensinogen Gene Among Nigerians

1997 • 101 citations

Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study

1996 • 101 citations

Essential Hypertension and 5′ Upstream Core Promoter Region of Human Angiotensinogen Gene

1997 • 97 citations

Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota

1995 • 92 citations

The Angiotensinogen T235 Variant and the Use of Antihypertensive Drugs in a Population-Based Cohort

1997 • 90 citations

Polymorphism of Angiotensin Converting Enzyme, Angiotensinogen, and Apolipoprotein E Genes in a Japanese Population With Cerebrovascular Disease

1997 • 87 citations

Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms, Plasma Levels, Cardiac Dimensions A Twin Study

1997 • 85 citations

A -Acting DNA Element Located between TATA Box and Transcription Initiation Site Is Critical in Response to Regulatory Sequences in Human Angiotensinogen Gene

1996 • 83 citations

Blood Pressure and the M235T Polymorphism of the Angiotensinogen Gene

1996 • 82 citations

U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM

1995 • 81 citations

M235T variant of the human angiotensinogen gene in unselected hypertensive patients

1993 • 80 citations

Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset

1995 • 80 citations

Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension

1997 • 78 citations

A Molecular Variant of Angiotensinogen Is Associated With Diabetic Nephropathy in IDDM

1996 • 77 citations

Associations of candidate loci angiotensinogen and angiotensin-converting enzyme with severe hypertension: The NHLBI family heart study

1997 • 75 citations

Genetic Variability in the Renin-Angiotensin System: Prevalence of Alleles and Genotypes

1997 • 74 citations

Contribution of Angiotensin I Converting Enzyme Gene Polymorphism and Angiotensinogen Gene Polymorphism to Blood Pressure Regulation in Essential Hypertension

1998 • 72 citations

Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese

1997 • 70 citations

Angiotensinogen and angiotensin-I converting enzyme gene polymorphisms and the risk of coronary artery disease in Chinese

1997 • 70 citations

A Mouse View of Hypertension

1997 • 66 citations

Angiotensinogen Gene Polymorphisms in IDDM Patients With Diabetic Nephropathy

1996 • 66 citations

Effect of the angiotensinogen gene Met235$Thr variant on blood pressure and other cardiovascular risk factors in two Japanese populations

1995 • 64 citations

Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM

1996 • 63 citations

Molecular variant M235T of the angiotensinogen gene is associated with essential hypertension in Taiwanese

1997 • 62 citations

Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica

1996 • 60 citations

Associations between candidate loci angiotensin-converting enzyme and angiotensinogen with coronary heart disease and myocardial infarction: The NHLBI family heart study

1997 • 59 citations

Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes

1997 • 58 citations

Angiotensinogen in Human Essential Hypertension

1996 • 56 citations

Gender-Specific Association of M235T Polymorphism in Angiotensinogen Gene and Diabetic Nephropathy in NIDDM

1998 • 54 citations

Angiotensinogen gene polymorphism in Japanese patients with hypertrophic cardiomyopathy

1997 • 51 citations

Angiotensinogen Polymorphism M235T, Hypertension, and Nephropathy in Insulin-Dependent Diabetes

1996 • 51 citations

M235??? T polymorphism of the angiotensinogen gene predicts hypertension in the elderly

1996 • 47 citations

Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter.

1994 • 45 citations

Dinucleotide repeat polymorphism in the human angiotensinogen gene

1991 • 44 citations

Angiotensinogen Gene Variation Associated With Variation in Blood Pressure in Aboriginal Canadians

1997 • 43 citations

Lack of Association of Polymorphisms of the Angiotensin Converting Enzyme and Angiotensinogen Genes With Nonfamilial Hypertrophic or Dilated Cardiomyopathy

1997 • 41 citations

Angiotensinogen gene M235T polymorphism is not associated with diabetic nephropathy

1996 • 41 citations

Genetic basis of left ventricular remodeling after myocardial infarction

1996 • 41 citations

Human Renin-Dependent Hypertension in Rats Transgenic for Human Angiotensinogen

1996 • 38 citations

Analysis of Two Variants of the Angiotensinogen Gene in Essential Hypertensive African-Americans

1994 • 33 citations

Angiotensinogen Met235-->Thr polymorphism in a London normotensive and hypertensive black and white population.

1994 • 33 citations

Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma.

1995 • 32 citations

Molecular Variants of the Angiotensinogen Gene and Hypertension in a Japanese Population.

1994 • 26 citations

Frequencies of the angiotensinogen gene and angiotensin I converting enzyme (ACE) gene polymorphisms in African Americans.

1994 • 25 citations

Genetic variants of the renin–angiotensin system and ambulatory blood pressure in essential hypertension

1997 • 24 citations

Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus

1997 • 23 citations

A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM

1996 • 19 citations

T235 variant of the angiotensinogen gene and blood pressure in the Chilean population

1998 • 19 citations

Angiotensinogen gene polymorphisms in IDDM patients with diabetic nephropathy

1996 • 18 citations

M235T polymorphism of the angiotensinogen gene and hypertension in Chinese

1998 • 16 citations

Angiotensinogen-M235T genotype and post-transplant hypertension

1996 • 16 citations

Ambulatory Blood Pressure Monitoring for Detecting the Relation Between Angiotensinogen Gene Polymorphism and Hypertension

1997 • 15 citations

No Effect of Genetic Variation at the Angiotensinogen Locus on Ambulatory Blood Pressure Level in Normotensive Subjects

1997 • 8 citations