Histone H3 specific acetyltransferases are essential for cell cycle progression

The language of covalent histone modifications

2000 • 8,260 citations

Histone Acetyltransferases

2001 • 1,745 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

FACT, a Factor that Facilitates Transcript Elongation through Nucleosomes

1998 • 637 citations

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins

1999 • 533 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Global histone acetylation and deacetylation in yeast

2000 • 457 citations

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p

1999 • 452 citations

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo

1998 • 444 citations

Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement.

1994 • 410 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes

1999 • 371 citations

Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes

2001 • 359 citations

Functional Organization of the Yeast SAGA Complex: Distinct Components Involved in Structural Integrity, Nucleosome Acetylation, and TATA-Binding Protein Interaction

1999 • 358 citations

Esa1p Is an Essential Histone Acetyltransferase Required for Cell Cycle Progression

1999 • 347 citations

Genetic Analysis of Histone H4: Essential Role of Lysines Subject to Reversible Acetylation

1990 • 346 citations

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

1998 • 318 citations

Histone Acetyltransferase HBO1 Interacts with the ORC1 Subunit of the Human Initiator Protein

1999 • 315 citations

ESA1 is a histone acetyltransferase that is essential for growth in yeast

1998 • 309 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

1998 • 287 citations

Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes

1997 • 277 citations

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

1994 • 276 citations

Cell cycle-regulated histone acetylation required for expression of the yeast HO gene

1999 • 275 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Role of the histone “tails” in the folding of oligonucleosomes depleted of histone H1.

1992 • 238 citations

Global Role for Chromatin Remodeling Enzymes in Mitotic Gene Expression

2000 • 232 citations

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

1998 • 230 citations

The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF_II30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex

2000 • 221 citations

The Saccharomyces cerevisiae DNA Polymerase α Catalytic Subunit Interacts with Cdc68/Spt16 and with Pob3, a Protein Similar to an HMG1-Like Protein

1997 • 204 citations

Role for ADA/GCN5 Products in Antagonizing Chromatin-Mediated Transcriptional Repression

1997 • 203 citations

Gcn4 Activator Targets Gcn5 Histone Acetyltransferase to Specific Promoters Independently of Transcription

2000 • 201 citations

The ADA Complex Is a Distinct Histone Acetyltransferase Complex in Saccharomyces cerevisiae

1999 • 172 citations

Crystal Structure of Yeast Esa1 Suggests a Unified Mechanism for Catalysis and Substrate Binding by Histone Acetyltransferases

2000 • 155 citations

Acetylation Increases the α-Helical Content of the Histone Tails of the Nucleosome

2000 • 152 citations

Overlapping roles for the histone acetyltransferase activities of SAGA and Elongator in vivo

2000 • 149 citations

Persistent Interactions of Core Histone Tails with Nucleosomal DNA following Acetylation and Transcription Factor Binding

1998 • 144 citations

The Role of Sas2, an Acetyltransferase Homologue of Saccharomyces cerevisiae, in Silencing and ORC Function

1997 • 134 citations

Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.

1996 • 132 citations

Modifying chromatin and concepts of cancer

1999 • 131 citations

Inhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters

2000 • 130 citations

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes

2000 • 122 citations

POB3 Is Required for Both Transcription and Replication in the Yeast Saccharomyces cerevisiae

2000 • 119 citations

SPT20/ADA5 Encodes a Novel Protein Functionally Related to the TATA-Binding Protein and Important for Transcription in Saccharomyces cerevisiae

1996 • 114 citations

Identification of Native Complexes Containing the Yeast Coactivator/Repressor Proteins NGG1/ADA3 and ADA2

1997 • 113 citations

Crystal structure of the histone acetyltransferase Hpa2: a tetrameric member of the Gcn5-related N-acetyltransferase superfamily

1999 • 105 citations

A DNA unwinding factor involved in DNA replication in cell-free extracts of Xenopus eggs

1999 • 102 citations

A role for the yeast SWI/SNF complex in DNA replication

1999 • 98 citations

ADA5/SPT20 Links the ADA and SPT Genes, Which Are Involved in Yeast Transcription

1996 • 96 citations

The Highly Conserved N-Terminal Domains of Histones H3 and H4 Are Required for Normal Cell Cycle Progression

1991 • 96 citations

Steady-state Levels of Histone Acetylation in Saccharomyces cerevisiae

2000 • 95 citations

Mediator–Nucleosome Interaction

2000 • 80 citations

Identification and Analysis of Yeast Nucleosomal Histone Acetyltransferase Complexes

1998 • 79 citations

Sas3 Is a Histone Acetyltransferase and Requires a Zinc Finger Motif

1999 • 78 citations

Architectural Transcription Factors and the SAGA Complex Function in Parallel Pathways To Activate Transcription

2000 • 75 citations

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2

1995 • 70 citations

Gcn5p is involved in the acetylation of histone H3 in nucleosomes

1997 • 62 citations

Nuclear Proteins Nut1p and Nut2p Cooperate To Negatively Regulate a Swi4p-DependentlacZReporter Gene inSaccharomyces cerevisiae

1998 • 53 citations

Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein Subunits

1998 • 52 citations

Histone hyperacetylation. Its effects on nucleosome core particle transitions

1988 • 49 citations

Histone Acetyltransferase Complexes and Their Link to Transcription

1999 • 49 citations

The Yeast Histone Acetyltransferase A2 Complex, but Not Free Gcn5p, Binds Stably to Nucleosomal Arrays

2000 • 46 citations

Mutations in Chromatin Components Suppress a Defect of Gcn5 Protein in Saccharomyces cerevisiae

1998 • 38 citations

Mediator?Nucleosome Interaction

2000 • 33 citations

The Gcn5·Ada Complex Potentiates the Histone Acetyltransferase Activity of Gcn5

1998 • 31 citations

Deleted Work

1955 • 0 citations